Novartis Nutrition Ag

The University of North Carolina at Chapel Hill

Eisai Company, Limited

Sandoz Nutrition Corporation

Ronald G Thurman

Heinz Schneider

John J Lemasters

Daniel P Rossignol

William J Christ

Michael D Lewis

Nigel Scott Cook

Glycine is indicated to prevent or treat acute or chronic graft rejection, optionally in combination with an immunosuppressant or an immunomodulating agent.

Therapeutic use for glycine

Disclosed is a rinse solution for rinsing organs and tissues prior to transplantation. The solution comprises, in one liter of solution: from 2 mM to 50 mM glycine; from 0.12 to 1.2 mM adenosine; monosaccharide, sodium, potassium, calcium and magnesium ions; and water for injection sufficient to make a liter of solution; said solution having a pH of about 6.0 to 7.5 and a concentration of potassium of less than 6 MEQ/L. Methods of making and using the solutions are also disclosed.

Rinse solution for organs and tissues

A method for treating a human having elevated tumor necrosis factor levels by administrating an effective amount of one of the amino acids glycine, alanine, or serine.

Amino acid compositions and use thereof in clinical nutrition

The invention provides a method for the treatment of endotoxic shock comprising administering to a human or other mammal in need of such a treatment an effective amount of choline for reducing endotoxin-induced injury and mortality and a nutritional composition comprising choline, whereby the composition provides a daily dosage of at least 1.5 g choline, the upper limit being 20 g of choline per day.

Treatment of endotoxic shock

A method for the inhibition and amelioration of alcholic liver disease in a mammal in need of such treatment by administering novel analogs of Lipid A which act as endotoxin antagonists. These antagonists compounds are found to inhibit the swift increase in alcohol metabolism which typically accompanies ingestion of alcohol and which may lead to the pathophysiological abnormalities associated with alcoholic liver disease.

Method for treating alcoholic liver disease

Method of modulating microcirculation

Composition comprising glycine and/or other amino acids are useful in treating or minimizing the effects of endotoxemia, hypoxia-reperfusion injury and infection.

Amino acid compositions and methods of treatment using same

A composition for storing tissue prior to transplantation is disclosed, wherein the tissue storage composition comprises a calcium channel blocker. Also disclosed is a method of storing tissue, comprising contacting the tissue to be stored with an amount of a calcium channel blocker sufficient to reduce tissue injury during storage under conditions such that viability of the tissue is maintained.

Calcium channel blockers to improve preservation of organs stored for

Disclosed is a rinse for preservation solution for organs and tissues selected for transplantation. The solution can be used at all temperatures from 0.degree. C. to normal body temperature and continues to be protective above 10.degree. C. Methods for preparing organs and tissues preserved in a preservation solution prior to transplant into a recipient are also disclosed.

Growing community of inventors

Chapel Hill, NC, United States of America

Ronald G Thurman