Sandia Corporation

Sandia National Laboratories

National Technology & Engineering Solutions of Sandia, LLC

Miroculus Inc.

Other

Integra Biosciences Ag

Sandia National Labroatories

Ronald Francis Renzi

Mark R Claudnic

Kamlesh D Patel

Steven Branda

Anup Kumar Singh

Paul Charles Galambos

Mais Jehan Jebrail

Gregory Jon Sommer

Anson Hatch

Mark S Derzon

Ying-Chih Wang

Scott M Ferko

James L Van De Vreugde

Jason A A West

Robert Meagher

Cameron Scott Ball

Blake A Simmons

Timothy J Shepodd

Kenneth A Peterson

Linda Domeier

Thomas D Perroud

Randolph R Kay

Kyle W Hukari

Liam D Claus

Victoria A VanderNoot

Stanley Alan Langevin

Noble Woo

Brent A Horn

David Marcus Tung

Scott Morris Maurer

Alfredo M Morales

Stewart K Griffiths

Robert Ward Crocker

Gregory Robert Bogart

James Frederick Stamps

Huu Minh Tran

John E Dec

Oscar Negrete

Karl Wally

Daniel Dadwa Yee

Hanyoup Kim

Bryan Carson

Michael S Bartsch

Gabriela S Chirica

Subhash L Shinde

William L Flower

Josh A Whaley

Todd W Lane

Boyd J Wiedenman

Zachary Bent

Mark D Zimmerman

William D Munslow

Aashish Priye

Julia A Fruetel

Isaac R Shokair

Ronald P Kensek

Mark A Grohman

Jonathan Ivers Helm

Thomas Kerr Lemp

Donald A Sheaffer

Kevin Schroder

Described herein are digital microfluidic (DMF) devices and corresponding methods for managing reagent solution evaporation during a reaction. Reactions on the DMF devices described here are performed in an air or gas matrix. The DMF devices include a means for performing reactions at different temperatures. To address the issue of evaporation of the reaction droplet especially when the reaction is performed at higher temperatures, a means for introducing a replenishing droplet has been incorporated into the DMF device. A replenishing droplet is introduced every time when it has been determined that the reaction droplet has fallen below a threshold volume. Detection and monitoring of the reaction droplet may be through visual, optical, fluorescence, colorimetric, and/or electrical means.

Evaporation management in digital microfluidic devices

The present invention relates, in part, to systems configured to obtain samples from an organism in an autonomous manner. Such systems can employ a cartridge configured to provide bait to attract an organism, as well as channels to store and/or test samples obtained from the organism.

Real time autonomous surveillance of pathogens

The present invention relates to microfluidic check valves, as well as fluidic cartridges including such check valves. In particular examples, the check valve includes a pre-stressed spring formed from a planar substrate. Various characteristics of the valves, such as size, profile, opening pressure, etc., can be tuned to provide desired performance when employed within a fluidic cartridge.

Check valves for microfluidic systems and methods thereof

Embodiments of fluid distribution manifolds, cartridges, and microfluidic systems are described herein. Fluid distribution manifolds may include an insert member and a manifold base and may define a substantially closed channel within the manifold when the insert member is press-fit into the base. Cartridges described herein may allow for simultaneous electrical and fluidic interconnection with an electrical multiplex board and may be held in place using magnetic attraction.

Fluid delivery manifolds and microfluidic systems

Apparatus for detecting radiation includes a sensor medium disposed within a cavity in a silicon-based substrate. An electrode arrangement is provided for collecting charge generated within the sensor medium by interactions with impinging radiation and drifted through the sensor medium. The electrode arrangement is constituted, in part, by a silicon portion of the substrate that is doped to increase its electrical conductivity and that defines part of the cavity wall.

Compact radiation detector

A system and method for fast control of the timing of combustion in an internal combustion engine, comprising actuating a fast-acting fuel-additive supply valve to meter a variable amount of fuel additive into a fuel stream, thereby forming an additive-enhanced fuel with an additive concentration that can be dynamically adjusted as fast as each engine cycle; injecting the additive-enhanced fuel directly or indirectly into a combustion chamber or into an intake port; and combusting the additive-enhanced fuel.

Additive-mixing fuel-injection system for internal combustion engines

An apparatus for detecting radiation is provided. In embodiments, at least one sensor is disposed on a surface of a wafer-like substrate. At least one sensor medium is fixed relative to the substrate, optically or electrically coupled to the sensor, and separated from the sensor by no more than the substrate thickness. An electronic signal-processing circuit is connected to the sensor and configured to produce an output when the sensor is stimulated by a product of an interaction between the sensor medium and impinging radiation. The sensor is configured to collect, from the sensor medium, charge and/or light produced within the sensor medium by interactions with impinging radiation.

A system for enhancing a nucleic acid sample may include a one pump, a denaturing chamber; a microfluidic hydroxyapatite chromatography device configured for performing hydroxyapatite chromatography on the nucleic acid sample, a sample collector, and tubing connecting the pump with the denaturing chamber, the hydroxyapatite chromatography device and the sample collector such that the pump may be used to move the nucleic acid sample from the denaturing chamber to the hydroxyapatite chromatography device and then to the sample collector.

Multiplexed microfluidic approach for nucleic acid enrichment

A directional neutron detector has an ion chamber formed in a dielectric material; a signal electrode and a ground electrode formed in the ion chamber; a neutron absorbing material filling the ion chamber; readout circuitry which is electrically coupled to the signal and ground electrodes; and a signal processor electrically coupled to the readout circuitry. The ion chamber has a pair of substantially planar electrode surfaces. The chamber pressure of the neutron absorbing material is selected such that the reaction particle ion trail length for neutrons absorbed by the neutron absorbing material is equal to or less than the distance between the electrode surfaces. The signal processor is adapted to determine a path angle for each absorbed neutron based on the rise time of the corresponding pulse in a time-varying detector signal.

Compact ion chamber based neutron detector

Embodiments of microfluidic hubs and systems are described that may be used to connect fluidic modules. A space between surfaces may be set by fixtures described herein. In some examples a fixture may set substrate-to-substrate spacing based on a distance between registration surfaces on which the respective substrates rest. Fluidic interfaces are described, including examples where fluid conduits (e.g. capillaries) extend into the fixture to the space between surfaces. Droplets of fluid may be introduced to and/or removed from microfluidic hubs described herein, and fluid actuators may be used to move droplets within the space between surfaces. Continuous flow modules may be integrated with the hubs in some examples.

Microfluidic hubs, systems, and methods for interface fluidic modules

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Tracy, CA, United States of America

Ronald Francis Renzi