Amgen Inc.

Ronald Forster

Sheldon B Moberg

Mark Dominis Holt

Francisca Tan-Malecki

Scott M Nunn

Son C Tran

Christian Plambech

Adam B McCullough

Matias Melander

Bjarke Lykke Ludvig Svendsen

Rasmus Øhlenschlæger

Lars Stenholt

Joseph Michael Iglesias

Gregory Gordon

Wael Mismar

Andrew Nathan King

Julian Jazayeri

Matthew Wayne Janke

Peter Dan Kaare Soelberg

Martin Hering

Jolita Seckute

Olivia Alice Henderson

Rasmus Øhlenschlaeger

Kristen Brown

An injector includes a housing having a syringe assembly and an actuating mechanism at least partially disposed within the housing. The syringe assembly includes a syringe barrel that stores a medicament to be injected into a user, a needle assembly, and a filter member disposed adjacent to the needle assembly. The actuating mechanism is operatively coupled to the syringe assembly and includes a torque spring that exerts a torque to urge the medicament through the filter member to be injected into the user. The actuating mechanism further includes a damper mechanism that exerts an opposing force to dampen the motion exerted by the torque spring.

Torque driven drug delivery device

An injector may include a container having a wall with an interior surface and a seal assembly with an interior surface, the interior surfaces of the wall and the seal assembly defining a closed sterile reservoir filled with a drug product. The injector may also include a fluid delivery system comprising a clean, unsheathed, rigid container needle having a point disposed only partially through the seal assembly in a storage state, and disposed through the interior surface of the seal assembly into the sterile reservoir in a delivery state. Further, the injection may include an actuator that is adapted to move the container needle from the storage state to the delivery state.

Injector and method of assembly

Drug delivery devices and related methods of assembly are disclosed. The drug delivery device may include a housing, a container, a trigger member, and an interlock assembly. The trigger member may be selectively moveable relative to the housing to activate operation of at least one activatable element of the drug delivery device. The interlock assembly may include a lever mounted rotatably relative to the housing, a proximity sensor moveable between a first position extending beyond an exterior surface of the housing and a second position retracted toward the housing, and a rotational biasing member operably connected to the proximity sensor via the lever. When the proximity sensor is in the first position, the interlock assembly may limit movement of the trigger member relative to the housing. The rotational biasing member may be configured to exert a torque biasing the proximity sensor toward the first sensor position.

Drug delivery device including seal member for needle of syringe

Method of assembling and filling a drug delivery device

A plunger configured as described herein provides geometry optimizations to minimize friction magnitude and variability during use by maintaining low deformation under large extrusion forces. More specifically, plunger embodiments described herein minimize a contact area between the plunger and a syringe or chamber, while also maintaining high contract pressures to maintain container closure integrity. Moreover, the plunger embodiments are configured to have minimal or no increase in the contact area under high loads associated with the delivery of viscous products.

Plungers for drug delivery devices

An injector may include a container having a wall with an interior surface and a seal assembly with an interior surface, the interior surfaces of the wall and the seal assembly defining a closed sterile reservoir filled with a drug product, including a granulocyte colony-stimulating factor (G-CSF). The injector may also include a fluid delivery system comprising a clean, unsheathed, rigid container needle having a point disposed only partially through the seal assembly in a storage state, and disposed through the interior surface of the seal assembly into the sterile reservoir in a delivery state. Further, the injection may include an actuator that is adapted to move the container needle from the storage state to the delivery state.

An injector () may include a container () having a wall () with an interior surface () and a seal assembly () with an interior surface (), the interior surfaces () of the wall () and the seal assembly () defining a closed sterile reservoir () filled with a drug product. The injector () may also include a fluid delivery system comprising a clean, unsheathed, rigid container needle () having a point () disposed only partially through the seal assembly () in a storage state, and disposed through the interior surface () of the seal assembly () into the sterile reservoir () in a delivery state. Further, the injection may include an actuator () that is adapted to move the container needle from the storage state to the delivery state.

Growing community of inventors

Simi Valley, CA, United States of America

Ronald Forster