The Procter Gamble Company

Morton-Norwich Products, Inc.

Norwich Eaton Pharmaceuticals, Inc.

Procter & Gamble Pharmaceuticals, Inc.

Wyeth

Other

Ronald E White

Thomas P Demuth, Jr

George C Wright

Stanford S Pelosi, Jr

Chia Nien Yu

John M Janusz

Benjamin E Blass

Stephen Joseph Hodson

Neil Thomas Fairweather

Gregory Kent Bosch

Christopher M Jackson

Chia-Nien Yu

A first embodiment of the security apparatus comprises a retaining collar; a plurality of segments forming a generally frusta-conical enclosure, with one or more of the segments having an access opening therein; and a lockable access door covering the opening. The retaining collar is separable into portions that conforms to the shape of the periphery and are coupled together around the structure. The segments have an upper portion that attaches to the collar; and have a bottom portion that extends radically downwardly from the collar at an angle of about 30 degree; with the radial edges interconnected forming the enclosure. A second embodiment of the apparatus secures a ladder supported on a wall and a retaining bar; a plurality of segments forming a generally semi-frusta-conical enclosure, with one or more of the segments having an access opening therein; and a lockable access door covering the opening.

Security cone-door for a ladder

The present invention relates to 1-N-amino-2-imidazolidinones and derivatives thereof which are effective as Kv1.5 potassium channel inhibitors providing atrial-selective antiarrhythmic agents. The present invention further relates to compositions comprising said Kv1.5 potassium channel inhibitors, and to methods for treating cardiac arrhythmia.

Kv1.5 potassium channel inhibitors

Antimicrobial dithiocarbamoyl quinolone compounds of the general formula: ##STR1## wherein (1) A.sup.1, A.sup.2, A.sup.3, R.sup.1, R.sup.3, R.sup.4, and R.sup.6 form any of a variety of quinolone and related heterocyclic structures similar to those known in the art to have antimicrobial activity; and

Antimicrobial dithiocarbamoyl quinolones

Antimicrobial lactam-quinolone compounds comprising a lactam-containing moiety linked to a quinolone moiety, of the formula: ##STR1## wherein (1) A.sup.1, A.sup.2, A.sup.3, R.sup.1, R.sup.4 and R.sup.6 generally form any of a variety of quinolone, naphthyridine or related cyclic moieties known in the art to have antimicrobial activity; and

Antimicrobial lactam-quinolones

A substantially flat collapsed plastic bag with an evacuation form unit insert positioned therein as manufactured to serve as a form about which the filled bag will collapse as it is emptied. The form unit comprises a ring for mounting the unit on the spout of the bag and a multi-channel form extending radially from the ring and hingedly connected thereto. A simple method is provided for manufacturing the bag with the form unit insert.

Antimicrobial carbacephem-quinolones

Compounds of Structure: ##STR1## as well as their pharmaceutically-acceptable salts and biohydrolyzable esters, and hydrates thereof, are effective antiinfective agents, useful in treating and preventing infection.

Antimicrobial carbapenem quinolones

The invention relates to antimicrobial 5-(N-heterosubstituted amino) quinolone compounds having a structure according to Formula (I) or (II): ##STR1## wherein (1) R.sup.1, R.sup.2, R.sup.3, R.sup.9 and R.sup.10 form any of a variety of quinolone and related heterocyclic structures similar to those known in the art to have antimicrobial activity; and

Quinolone 5-(N-heterosubstituted amino) antimicrobials

Compounds of structure: ##STR1## as well as their pharmaceutically-acceptable salts and biohydrolyzables esters, and hydrates thereof, are effective antiinfective agents, useful in treating and preventing infection.

Antimicrobial penem-quinolones

Antimicrobial quinolone thiourea compounds of the general formula: ##STR1## wherein (1) A.sup.1, A.sup.2, A.sup.3, R.sup.1, R.sup.3, R.sup.4, and R.sup.6 form any of a variety of quinolone and related heterocyclic structures similar to those known in the art to have antimicrobial activity; and

Antimicrobial quinolone thioureas

Antimicrobial quinolonyl lactam compounds comprising a lactam-containing moiety linked to a quinolone moiety, of the formula: ##STR1## wherein (1) A.sup.1, A.sup.2, A.sup.3, R.sup.1, and R.sup.4 generally form any of a variety of quinolone, naphthyridine or related cyclic moieties known in the art to have antimicrobial activity; and

Antimicrobial quinolonyl lactams

Antimicrobial quinolonyl lactam compounds comprising a lactam-containing moiety linked, by a non-ester linking moiety, to the 3-carboxy group of a quinolone moiety. These compounds are of the formula: ##STR1## wherein (1) R.sup.3, R.sup.4, and R.sup.5, together with bonds 'a' and 'b', form any of a variety of lactam-containing moieties similar to those known in the art to have antimicrobial activity;

The present invention provides methods of making compounds of the structure

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South Plymouth, NY, United States of America

Ronald E White