Warner-Lambert Company

Ronald E Seamans

James R Zeller

Rex A Jennings

Don R Johnson

Walter E Behnke

Randall L De Jong

Novel cyanocycloalkylacetic acids and esters as well as salts thereof and in particular 1-cyanocyclohexaneacetic acid and ethyl 1-cyanocyclohexaneacetate are described which are useful as intermediates in a process for the preparation of cyclic amino acids.

Cyanocycloalkylacetic acid and ester intermediates for preparing cyclic

An improved process for the preparation of 2-amino-3,5-dihydro-7-substituted-4H-pyrrolo[3,2-d]pyrimidin-4-ones is described wherein 2,6-diamino-3,5-dihydro-7-substituted-4H-pyrrolo[3,2-d]pyrimidin-4-one is converted to a diazonium salt which is subsequently catalytically hydrogenated to the desired compound, as well as valuable intermediates used in the process.

Process for the synthesis of

An improved process for the preparation of cyclic amino acids by a novel synthesis is described where a dinitrile derivative is converted in two steps to the desired products, as well as valuable intermediates used in the process.

Process for cyclic amino acid anticonvulsant compounds

Phosphate salts of the substituted acyl derivatives of octahydro-1H-indole-2-carboxylic acid are produced by treating a suitably substituted octahydro-1H-indole with phosphoric acid. The phosphate salts of the compounds and pharmaceutical compositions thereof are useful as antihypertensive agents.

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Holland, MI, United States of America

Ronald E Seamans