Koninklijke Philips Corporation N.v.

U.S. Philips Corporation

Nxp B.v.

Asml Netherlands B.v.

U.S. Phillips Corporation

St. Jude Medical Coordination Center Bvba

Mxp B.v.

Signify Holding B.v.

Technische Universiteit Delft

Koninklijke Philips Electronics N.v.

Invensas LLC

Koninklijke Philips Electronics B.v.

Ronald Dekker

Vincent Adrianus Henneken

Henricus G Maas

Marcus Cornelis Louwerse

Theodorus Martinus Michielsen

Henricus Godefridus Rafael Maas

Peter Dirksen

Antoon Marie Henrie Tombeur

Wilhelmus T Van Den Einden

Nicolaas Johannes Anthonius Van Veen

Ruediger Mauczok

Marcel Mulder

Bout Marcelis

Freerk Van Rijs

Cornelis Eustatius Timmering

Jaap Roger Haartsen

Armand Pruijmboom

Johannes Wilhelmus Weekemp

Martinus P Versleijen

Mareike K Klee

John Douglas Fraser

Remco Henricus Wilhelmus Pijnenburg

Eduard Johannes Meijer

Anja Van De Stolpe

Jacob Roger Haartsen

Dirk J Gravesteijn

Egbertus Reinier Jacobs

Wiebe B De Boer

Henricus G R Maas

Ronald Koster

Pascal De Graaf

Eugene Timmering

Adriaan Leeuwestein

Wilhelmus Mathias Clemens Dolmans

Angel Metodiev Savov

Hauke Pohlmann

Aslihan Arslan Carisey

Steffen Wilhelm Hahn

Bernardus Hendrikus Wilhelmus Hendriks

Johannes Petrus Maria Ansems

Johannes Wilhelmus Weekamp

Johan Hendrik Klootwijk

Martin Jacobus Johan Jak

Marc Andre De Samber

Christoph Gerard August Hoelen

Wojtek Sudol

Pieter Jan Van Der Zaag

Freddy Roozeboom

Franciscus Johannes Gerardus Hakkens

Heribert Baldus

Wouter Anthon Soer

Willem Franke Pasveer

Klaus Reimann

Antonia Cornelia Van Rens

Anco Heringa

Olaf Wunnicke

Derk Reefman

Jan Willem Slotboom

Max Oskar Köhler

Robertus Adrianus Maria Wolters

Engel Johannes Knibbe

Roger Peter Anna Delnoij

Wibo Daniel Van Noort

Lukas Leyten

Biju Kumar Sreedharan Nair

Alphonsus Tarcisius Jozef Maria Schipper

Tiemen Poorter

Greja Johanna Adriana Maria Verheijden

Shunmugavelu D Sokka

Wolfgang Schnitt

Pieter W Hooijmans

Cornelis Adrianus Henricus Antonius Mutsaers

Henri Marie Joseph Boots

John Brean Mills

Petrus G Baltus

Derk Jan Adelerhof

Petra Elisabeth De Jongh

Christina Adriana Renders

Doede Terpstra

Eric Cornelis Egbertus Van Grunsven

Marc Godfriedus Marie Notten

Johannes P M Ansems

Frederikus R Huisman

Frank Cornelis Penning

Frederik Van Der Graaf

Johannes Fransiscus Maria Velthuis

Axel Winkel

Stephan Schlumbohm

Stefan Tiensuu

Adrianus Johannes Maria Van Tuijl

Holger Schligtenhorst

Antonius Lucien Adrianus Maria Kemmeren

Petrus H C Magnee

Andreas Gakis

Remco Alphonsus Hendrikus Breen

Antonius L A M Kemmeren

Ingrid Annemarie Rink

Pascal Henri Leon Bancken

Ramon Jacob Havens

Antonius Johannes Janssen

Devices, systems, and methods relating to intraluminal imaging are disclosed. In an embodiment, an intraluminal imaging device is disclosed. One embodiment of the intraluminal imaging device comprises a flexible elongate member configured to be inserted into a body lumen of a patient, the flexible elongate member comprising a proximal portion and a distal portion. The intraluminal imaging device further comprises an ultrasound imaging assembly disposed at the distal portion of the flexible elongate member. The imaging assembly comprises a support member, a flexible substrate positioned around the support member, a plurality of ultrasound transducer elements integrated in the flexible substrate, and a plurality of control circuits disposed on the flexible substrate at a position proximal to the plurality of transducer elements. The plurality of control circuits has an outer profile that does not extend beyond an outer profile of the plurality of transducer elements.

Intraluminal ultrasound scanner with reduced diameter

An intraluminal ultrasound imaging device includes a flexible elongate member configured to be positioned within a body lumen of a patient. The flexible elongate member includes a proximal portion and a distal portion. The device also includes an ultrasound imaging assembly disposed at the distal portion of the flexible elongate member. The ultrasound imaging assembly is configured to obtain imaging data of the body lumen. The ultrasound imaging assembly includes a transducer array including a substrate, a silicon oxide layer disposed over the substrate, and a plurality of rows of micromachined ultrasound transducer elements disposed on the silicon oxide layer. Two of the plurality of rows of micromachined ultrasound transducer elements are spaced apart by a trench formed by etching through a screen formed in the silicon oxide layer. Associated devices, systems, and methods are also provided.

Intraluminal ultrasound imaging device comprising a substrate separated into a plurality of spaced-apart segments, intraluminal ultrasound imaging device comprising a trench, and method of manufacturing

An intraluminal ultrasound imaging device includes a flexible elongate member configured to be inserted into a body lumen of a patient, the flexible elongate member comprising a proximal portion and a distal portion. The device includes an ultrasound scanner assembly disposed at the distal portion of the flexible elongate member. The ultrasound scanner assembly includes a flexible substrate comprising a longitudinal width extending from an inner edge to an outer edge; a control region embedded in the flexible substrate; a transducer region embedded in the flexible substrate; and a window region disposed between the outer edge of the flexible substrate and the transducer region, and wherein the window region, the transducer region, and the control region are radially arranged relative to one another. Associated devices, systems, and methods are also described.

Rolled flexible substrate with integrated window for intraluminal ultrasound

An intraluminal ultrasound imaging device includes a flexible elongate member configured to be inserted into a body lumen of a patient, the flexible elongate member comprising a proximal portion and a distal portion. The device also includes an ultrasound scanner assembly disposed at the distal portion of the flexible elongate member. The ultrasound scanner assembly includes a flexible substrate; a transducer region positioned on the flexible substrate; and a control region positioned on the flexible substrate, wherein the transducer region and the control region are radially arranged relative to one another. Associated devices, systems, and methods are also described.

Rolled flexible substrate for intraluminal ultrasound imaging device

The present invention relates to an ultrasound transducer assembly (), in particular for intra vascular ultrasound systems. The assembly () comprises a transducer array () including a plurality of transducer elements () for transmitting and receiving ultrasound waves. Two support elements () are provided for supporting the transducer array () in a curved or polygonal shape. The support elements () are connected via a flexible connection layer () to the transducer array () for flexibly connecting the support elements () to the transducer array ().

Ultrasound transducer assembly and method for manufacturing an ultrasound transducer assembly

A large aperture CMUT transducer array is formed of a plurality of adjacently located tiles of CMUT cells. The adjacent edges of the tiles are formed by an anisotropic etch process, preferably a deep reactive ion etching process which is capable of cutting through the die and its substrate while maintaining vertical edges in close proximity to the CMUT cells at the edge of the tile. This enables the CMUT cells of continuous rows or columns to exhibit a constant pitch over multiple CMUT cell tiles. The tiles also contain interconnect electrodes along an edge for making electrical connections to the tiles with flex circuit.

Tiled CMUT dies with pitch uniformity

The present invention relates to an ultrasound transducer assembly, in particular for intravascular ultrasound systems. The ultrasound transducer assembly comprises at least one silicon substrate element including an ultrasound transducer element for emitting and receiving ultrasound waves and including electrical connectors for electrically connecting the transducer element. The substrate element has a top surface, a bottom surface and a side surface connecting the top surface and the bottom surface. An isolation layer forms the side surface for electrically isolating the substrate element.

The present invention relates to an ultrasound transducer device comprising at least one cMUT cell () for transmitting and/or receiving ultrasound waves, the cMUT cell () comprising a cell membrane () and a cavity () underneath the cell membrane. The device further comprises a substrate () having a first side () and a second side (), the at least one cMUT cell () arranged on the first side () of the substrate (). The substrate () comprises a substrate base layer () and a plurality of adjacent trenches () extending into the substrate () in a direction orthogonal to the substrate sides (), wherein spacers () are each formed between adjacent trenches (). The substrate () further comprises a connecting cavity () which connects the trenches () and which extends in a direction parallel to the substrate sides (), the trenches () and the connecting cavity () together forming a substrate cavity () in the substrate (). The substrate () further comprises a substrate membrane () covering the substrate cavity (). The substrate cavity () is located in a region of the substrate () underneath the cMUT cell (). The present invention further relates to a method of manufacturing such ultrasound transducer device.

Ultrasound transducer device and method of manufacturing the same

An ultrasound transducer arrangement () is disclosed comprising a plurality of substrate islands () spatially separated and electrically interconnected by a flexible polymer assembly () including electrically conductive tracks providing said electrical interconnections, said plurality including a first substrate island () comprising a plurality of ultra sound transducer cells () and a second substrate island () comprising an array of external contacts for connecting the ultrasound sensor arrangement to a flexible tubular body including a coaxial wire assembly () comprising a plurality of coaxial wires () each having a conductive core () covered by an electrically insulating sleeve (); and an electrically insulating body () having a first main surface (), a second main surface () and a plurality of through holes () each extending from the first main surface to the second main surface and coated with an electrically conductive member, wherein each coaxial wire comprises an exposed terminal core portion mounted in one of said though holes from the first main surface, and wherein each through hole is sealed by a solder bump () on the second main surface such that the ultrasound transducer arrangement can be directly mounted on the flexible tubular body without the need for a PCB.

Ultrasound transducer arrangement and assembly, coaxial wire assembly, ultrasound probe and ultrasonic imaging system

An integrated circuit array, in particular for two dimensional sensor arrays such as ultrasound imaging systems is disclosed. The integrated circuit array () comprises a plurality of integrated circuit elements () each formed in a substrate (), wherein the substrates are separated from each other. The array comprises a flexible and/or stretchable connection layer () connected to the integrated circuit elements for flexibly connecting the integrated circuit elements to each other. The array further comprises a plurality of electrical interconnects () for electrically connecting the integrated circuit elements to each other, wherein the electrical interconnects are formed as metal lines in one piece with integrated interconnects of the integrated circuit elements.

Integrated circuit array and method for manufacturing an array of integrated circuits

A CMUT transducer array comprising a first column () of spaced CMUT cells on at least one silicon island, a second column () of spaced CMUT cells on at least one further silicon island, the second column being staggered in alignment with the first column such that cells of the second column are partially located in spaces between successive cells of the first column, the first column and the second column being spaced apart by a gap, and a flexible foil retaining the respective silicon islands, the flexible foil comprising conductive interconnects.

Catheter transducer with staggered columns of micromachined ultrasonic transducers

The present invention relates to an electronic circuit arrangement () comprising: a substrate () having a first surface () and a second surface (), an electronic circuit, an electrical connection part () for providing an electrical connection to the electronic circuit and being arranged on the first surface (), and at least one electrical wire (). The electrical wire () comprises at least one conductive core () and an isolation () surrounding the conductive core (). An end portion () of the electrical wire () is an isolation-free portion for allowing access to the conductive core (), wherein the end portion () of the electrical wire () is connected to the electrical connection part (). At least one through-hole () extending from the first surface () to the second surface () is provided in the substrate (), wherein the electrical wire () is arranged through the through-hole ().

Electronic circuit arrangement and method of manufacturing the same

The present invention relates to an ultrasound transducer assembly (), in particular for intravascular ultrasound systems. The ultrasound transducer assembly comprises at least one silicon substrate element () including an ultrasound transducer element () for emitting and receiving ultrasound waves and including electrical connectors for electrically connecting the transducer element. The substrate element has a top surface (), a bottom surface () and a side surface connecting the top surface and the bottom surface. An isolation layer () forms the side surface for electrically isolating the substrate element.

Disclosed is a device () for cardiac electrophysiology screening comprising a substrate () comprising a cavity (), said substrate carrying a deformable layer () extending over said cavity (), wherein a portion of said deformable layer () covers said cavity and acts as a membrane over said cavity (), said portion having a surface comprising a pattern of grooves () and carrying a multi-electrode structure ('); and a plurality of cardiomyocytes () assembled in at least some of said grooves (). A method of manufacturing such a device () is also disclosed.

Cardiomyocyte containing device, manufacturing method and measuring method

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Eindhoven, Netherlands

Ronald Dekker