Albert Einstein College of Medicine

Ronald D Seidel, Iii

Steven Craig Almo

Sarah C Garrett-Thomson

Brandan S Hillerich

James D Love

The present disclosure provides variant PD-L1 immunomodulatory polypeptides, and fusion polypeptides comprising the variant immunomodulatory peptides. The present disclosure provides T-cell modulatory multimeric polypeptides, and compositions comprising same, where the T-cell modulatory multimeric polypeptides comprise a variant immunomodulatory polypeptide of the present disclosure. The present disclosure provides nucleic acids comprising nucleotide sequences encoding the T-cell modulatory multimeric polypeptides, and host cells comprising the nucleic acids. The present disclosure provides methods of modulating the activity of a T cell; the methods comprise contacting the T cell with a T-cell modulatory multimeric polypeptide of the present disclosure.

Variant PD-L1 polypeptides, T-cell modulatory multimeric polypeptides, and methods of use thereof

Methods and systems for high-throughput Identification of receptor:ligand interactions are provided. Throughout this application various publications are referred to in parentheses. Full citations for these references may be found at the end of the specification. The disclosures of these publications, and all patents, patent application publications and books referred to herein, are hereby incorporated by reference in their entirety into the subject application to more fully describe the art to which the subject invention pertains.

Methods for high throughput receptor:ligand identification

Methods and systems for high-throughput identification of receptor:ligand interactions are provided.

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Larchmont, NY, United States of America

Ronald D Seidel, Iii