University of California

The General Hospital Corporation

Sequoia Sciences, Inc.

Ronald Buckle

Graham Johnson

Rudolph Emile Tanzi

Robert Jason Herr

William C Mobley

Steven L Wagner

Nicholas James Mayhew

Kevin D Rynearson

Michael A Ellis

Gary R Eldridge

Zhongping Huang

John Edward Reilly

Provided herein are compounds and methods for treating a disorder associated with aberrant A&#x3b2; peptide levels, including Alzheimer's disease.

Potent gamma-secretase modulators

Provided herein are compounds and methods for treating a disorder associated with aberrant A3 peptide levels, including Alzheimer's disease. Provided herein are compositions and methods for treating a disorder associated with aberrant A&#x3b2; peptide levels, including AD. Provided herein are compounds of Formula (A) or a pharmaceutically acceptable salt thereof, wherein, L' is selected from the group consisting of C(O), C(R1)(R2), substituted or unsubstituted &#x2014;C2-6 alkylene-, and substituted or unsubstituted &#x2014;C3-6 cycloalkylene. 

Certain multi-cyclic compounds and compositions thereof are useful for reducing or inhibiting the growth of bacterial biofilms and for controlling bacterial biofilm infections. Such compounds and compositions are also useful in methods for reducing or inhibiting the growth of biofilms and for controlling bacterial biofilm infections involving biofilms.

Inhibitors of bacterial biofilms and related methods

Growing community of inventors

Delmar, NY, United States of America

Ronald Buckle