Bend Research, Inc.

Pfizer Corporation

Ronald Arthur Beyerinck

Roderick Jack Ray

Dana Marie Settell

Dan E Dobry

Ken R Spence

Dwayne Thomas Friesen

Heather L M Deibele

William John Curatolo

Avinash G Thombre

Daniel Elmont Dobry

Mark B Chidlaw

Heather L M Diebele

David D Newbold

Leah Elizabeth Appel

Kelly L Smith

Kenneth C Waterman

Michael B Fergione

Michael C Roy

Leah A Appel

Kevin Douglas Grove

Danni Supplee

Heather Lynn Deibele

Kenny Ray Spence

Heather Lynn Melcher Deibele

Spray drying processes are used to form pharmaceutical compositions comprising a solid amorphous dispersion of a drug and a polymer.

Spray drying processes for forming solid amorphous dispersions of drugs and polymers

Conventional spray-drying methods are improved by incorporation of a pressure nozzle and a diffuser plate to improve the flow of drying gas and a drying chamber extension to increase drying time, such improvements leading to the formation of homogeneous solid dispersions of drugs in concentration-enhancing polymers.

Method for making homogeneous spray-dried solid amorphous drug dispersions utilizing modified spray-drying apparatus

A secondary drying process is disclosed for removing residual solvent from drug-containing particles that have been formed by solvent-based processes, the secondary drying process utilizing a combination of vacuum, agitation, and a stripping gas.

Drying of drug-containing particles

A controlled release dosage form has a coated core with the core comprising a drug-containing composition and a water-swellable composition, each occupying separate regions within the core. The drug-containing composition comprises a low-solubility drug and a drug-entraining agent. The coating around the core is water-permeable, water-insoluble and has at least one delivery port therethrough. A variety of formulations having specific drug release profiles are disclosed.

Hydrogel-driven drug dosage form

Homogeneous solid amorphous dispersions of drugs in concentration-enhancing polymers are formed in desirable larger particle sizes with minimal fines by using an atomizer and process conditions capable of producing droplets having an average diameter of at least 50 microns and a Dof at least 10 microns.

Method for making homogeneous spray-dried solid amorphous drug dispersions using pressure nozzles

A controlled release dosage form for sertraline has a core comprising a sertraline-containing composition and a water-swellable composition wherein the water-swellable composition is in a separate region within the core. A coating around the core is water-permeable, water-insoluble, and has at least one delivery port therethrough. In one embodiment, the dosage form releases sertraline to the use environment at an average rate of 6 to 10 wt % per hour from the second to the twenth hour after introduction to a use environment and less than about 25 wt % for the first two hours and at least 70 wt % by the twelfth hour, where the percentages correspond to the mass of drug released from the tablet divided by the total mass of drug originally present in the tablet. In another embodiment, the dosage form releases less than about 25 wt % of sertraline to the use environment by the second hour after introduction of the dosage form to the use environment, and delivers at least 25 wt % from the eighth to the twenty-fourth hour.

Hydrogel-driven layered drug dosage form

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Bend, OR, United States of America

Ronald Arthur Beyerinck