Corning Incorporated

Ronald Allen Faris

Vasiliy Nikolaevich Goral

Po Ki Yuen

Odessa Natalie Petzold

Joydeep Lahiri

Yulong Hong

Jin Liu

Olivia Grace Weeks

Miya Yi-Cheng Hsieh

Miya (Yi-Cheng) Hsieh

Cell culture compositions containing LFM-A13 or a structurally related compound can enhance global hepatic function. For example, LFM-A13 is shown to enhance levels of a broad variety of drug metabolism enzymes, including CYP enzymes, and other hepatic enzymes. LFM-A13 is also shown to promote differentiation of stem cells into hepatocytes. LFM-A13 and structurally related compounds can be used in cell culture to enhance global drug metabolism of liver cells for enhanced in vitro study the effects of drug metabolism on other candidate drug compounds.

Cell culture medium for enhanced hepatocyte function

A microfluidic cell culture apparatus includes a cell retention chamber and a perfusion channel. The cell retention chamber has a structured surface. The structured surface includes a major surface from which a plurality of projections extends into the chamber. The plurality of projections are arranged to suspend cells cultured in the chamber above the major surface. The first perfusion channel is configured to provide laminar flow of a fluid through the channel and forms a plurality of openings in communication with the cell retention chamber. The openings are configured to prevent cells from the retention chamber from entering the perfusion channel.

Microfluidic device for cell culture

Growing community of inventors

Elmira, NY, United States of America

Ronald Allen Faris