Geron Corporation

Ronald A Pruzan

Scott L Weinrich

Sergei M Gryaznov

Alain Philippe Vasserot

Serge P Lichtsteiner

Edward M Atkinson, Iii

Krisztina Pongracz

James T Kealey

Daria Zielinska

Jeffrey Lindquist

Nam Woo Kim

Fred Wu

Jeffrey N Lindquist

This invention relates to compounds useful for inhibiting telomere elongation. More specifically, the invention provides nucleotide analogs that are incorporated into telomeres by telomerase thereby inhibiting elongation of telomeres. The compounds are use in treating cancer and other cell proliferative diseases.

Guanine analogs as telomerase substrates and telomere length affectors

Provided herein are antisense oligonucleotides that can effectively prevent or decrease c-myc protein expression as well as decrease overall rates of cell proliferation in in vitro and mammalian in vivo models of cell proliferative disorders as well as methods for using the same.

C-myc antisense oligonucleotides and methods for using the same to treat cell-proliferative disorders

This invention relates to compounds useful for inhibiting telomere elongation. More specifically, the invention provides nucleotide analogs that are incorporated into telomeres by telomerase thereby inhibiting elongation of telomeres. The compounds are useful in treating cancer and other cell proliferative diseases.

This invention provides inhibitory polynucleotides, such as antisense molecules, directed against accessible regions in the telomerase ribonucleoprotein. The polynucleotides are useful for inhibiting the activity of telomerase in cells and for treating cancer.

Inhibitory polynucleotides directed against the RNA component of telomerase

This invention provides purified telomerase and methods of purifying it. The methods involve the use of several sequential steps, including the use of matrices that bind molecules bearing negative charges, matrices that bind molecules bearing positive charges, intermediate-selectivity matrices, methods that separate molecules based on their size, shape, or buoyant density, and by affinity purification.

Producing telomerase activators and inhibitors by screening with purified telomerase

Using purified telomerase to identify telomerase activators and inhibitors

Methods for purifying telomerase

Purified telomerase

This invention provides purified human telomerase and methods of purifying it. The methods involve the use of several sequential steps, including the use of a first matrix that binds molecules bearing negative charges, a matrix that binds molecules bearing positive charges, a second matrix that binds molecules bearing negative charges, an affinity purification step and a matrix that separates molecules according to their size.

Purified telomerose

Methods of detecting the RNA component of telomerase, diagnosing cancer, and determining its prognosis using polynucleotides that hybridize to the RNA component of mammalian telomerase in a sample.

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Palo Alto, CA, United States of America

Ronald A Pruzan