Boehringer Ingelheim Pharmaceuticals, Inc.

Parion Sciences, Inc.

Ronald A Aungst, Jr

Daniel R Goldberg

Ming-Hong Hao

Derek Cogan

Zhaoming Xiong

Abdelhakim Hammach

Matthew Russell Netherton

Michael Ross Johnson

Neil Moss

Pier Francesco Cirillo

Lifen Wu

Donghong Amy Gao

William Robert Thelin

Victor Marc Kamhi

Kevin Chungeng Qian

Mark Stephen Ralph

Amy L Davis

Alan David Swinamer

William R Thelin

Provided are dithiol mucolytic agents. These agents increase the liquefaction of mucus in a patient with excessive mucus or mucus with increased viscoelastic, cohesive, or adhesive properties. Also provided are a variety of methods of treatment using these inventive mucolytic agents.

Dithiol mucolytic agents

Disclosed are compounds of formula (I) which inhibit production of cytokines involved in inflammatory processes and are thus useful for treating diseases and pathological conditions involving inflammation such as chronic inflammatory disease. Also disclosed are processes for preparing these compounds and pharmaceutical compositions comprising these compounds.

Cytokine inhibitors

Disclosed are compounds of formula (I) Where Ar, X, R, R, Rand Rare defined herein. The compounds of the invention inhibit production of cytokines and are thus useful for treating cytokine mediated diseases. Also disclosed are processes for preparing these compounds and pharmaceutical compositions comprising these compounds.

Triazole compounds

Disclosed are compounds of formula (I) The compounds inhibit production of cytokines involved in inflammatory processes and are thus useful for treating diseases and pathological conditions involving inflammation such as chronic inflammatory disease. Also disclosed are processes for preparing these compounds and the pharmaceutical compositions comprising these compounds.

Anti-cytokine heterocyclic compounds

Disclosed are compounds of formula (I) Where Ar, X, Y, Q, W, R, R, R, Rand Rare defined herein. The compounds of the invention inhibit production of cytokines involved in inflammatory processes and are thus useful for treating diseases and pathological conditions involving inflammation such as chronic inflammatory disease. The compounds are also useful for treating diseases or conditions related to oncology and anticoagulant or fibrinolytic therapy. Also disclosed are processes for preparing these compounds and pharmaceutical compositions comprising these compounds.

Growing community of inventors

Clifton Park, NY, United States of America

Ronald A Aungst, Jr