Novartis Ag

Inspire Pharmaceuticals, Inc.

Ciba Vision Corporation

Qlt Inc.

Valeant Pharmceuticals International, Inc.

Romulus Kimbro Brazzell

Peter Anthony Campochiaro

Michael Kaleko

Tianci Luo

Jeanette Marjorie Wood

Katharine Hilary Dixon

Frances Elizabeth Kane

José L Boyer

John C Ice, Jr

Kurt E Brubaker

Reza M Haque

Joseph B Boyd

Robert J Dempsey

Methods are provided for the treatment of ocular neovascularization by increasing, in an individual afflicted with ocular neovascularization, in vivo concentrations of an endostatin protein in the ocular tissues of the individual to an ocular neovascularization inhibiting effective amount, where the endostatin protein has anti-ocular neovascularization activity in vivo.

Method for treating ocular neovascularization

The present invention describes an improved photodynamic treatment to treat subfoveal choroidal neovascularization (CNV).

Method for treating neovascularization

The present invention relates to a method for treating non-infectious, inflammatory chronic posterior blepharitis in a subject. The present invention also relates to a method for treating chronic posterior blepharitis in a subject for over two weeks. The method comprises identifying a subject in need thereof, and topically administering to the eye of the subject a pharmaceutical formulation consisting essentially of an effective amount azithromycin. The present invention further relates to a method for treating dry eye secondary to blepharitis in a subject. The method comprises the steps of: identifying a subject suffering from dry eye secondary to posterior blepharitis, and topically administering to the eye of the subject a pharmaceutical formulation comprising an effective amount of azithromycin. The present invention further relates to method for reducing contact lens intolerance of a subject due to blepharitis or dry eye secondary to blepharitis.

Method of treating blepharitis

The invention relates to the use of certain phthalazines in the preparation of medicaments for the treatment of ocular neovascularization.

Method for treating ocular neovascular diseases

The invention provides a method for treating or preventing ocular neovascularization. The method administers an effective amount of a staurosporine derivative to treat or prevent retinal or choroidal neovascularization. In each case, the effect on the pathologic blood vessels is dramatic and profound with complete or near-complete inhibition, but there is no identifiable toxic effect on mature retinal vessels.

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Alpharetta, GA, United States of America

Romulus Kimbro Brazzell