Farmitalia Carlo Erba S.r.l.

Farmitalia Carlo Erba

Romeo Roncucci

Mario Varasi

Paolo Pevarello

Philippe L Dostert

Alberto Bonsignori

Franco Heidempergher

Jacqueline Lansen

Paolo Sarmientos

Antonella Isacchi

Laura Bergonzoni

Guy Mazue

Antonio Molinari

Marco Gerna

Carla Giorgetti

A method of making antibodies to hirudin by immunizing with an immunogenic composition containing polymerized hirudin monomers in the absence of carrier protein is taught.

Anti-hirudin polyclonal antibodies and their use for the identification, immunopurification and quantitative determination of hirudin

N-phenylalkyl substituted .alpha.-amino carboxamide derivatives of formula (I) ##STR1## wherein R is C.sub.1 -C.sub.8 alkyl, C.sub.3 -C.sub.8 cycloalkyl, furyl, thienyl, pyridyl or unsubstituted or substituted phenyl; A is a --(CH.sub.2).sub.m -- or --(CH.sub.2).sub.p --X--(CH.sub.2).sub.q -- group wherein X is --O--, --S-- or --NR.sub.4 --; R.sub.1, R.sub.2, R.sub.3, R'.sub.3, R.sub.4, n, m, p and q are as herein defined; and each of R.sub.5 and R.sub.6 is independently hydrogen or C.sub.1 -C.sub.6 alkyl, and the pharmaceutically acceptable salts thereof, are active on the central nervous system and can be used as anti-epileptic, anti-Parkinson, neuroprotective, antidepressant, antispastic and/or hypnotic agents in mammals.

N-phenylalkyl substituted .alpha.-amino carboxamide derivatives and

The present invention provides a polypeptide which is capable of binding specifically human basic fibroblast growth factor and human acidic fibroblast growth factor, a DNA sequence which encodes the polypeptide of the invention and a vector which incorporates a DNA sequence of the invention and which is capable, when provided in a transformed host, of expressing the polypeptide of the invention encoded by the DNA sequence. A host transformed with such a vector forms part of the invention also.

Extracellular form of the human fibroblast growth factor receptor

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Milan, Italy

Romeo Roncucci