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Sociedad Espanola De Especialidades Farmaco-terapeuticas S.a.

Sociedad Espanola De Especialidades Terepeuticas, S.a.

Sociedad Espanola De Especialidades Farmacotera Peuticas

Romeo R Andreoli

Xavier D Cirera

Leonida Bruseghini

Pedro P Lloveras

Jose P Irurre

Jose P Irrure

The dihydrodibenzocycloheptyliden-ethylpiperazine derivative has the formula: ##STR1## wherein R represents a substituent selected from the group consisting of --CH.dbd.CH.sub.2 ; --CO.sub.2 C.sub.2 H.sub.5 ; --CH.dbd.CH--CO.sub.2 CH.sub.3 ; ##STR2## and

Vasodilatory dihydrodibenzocycloheptyliden-ethylpiperazine derivatives

Dihydrodibenzocycloheptyliden-ethylene derivatives of the general formula: ##STR1## in which, R.sub.1 represents an alkyl group having from 1 to 4 carbon atoms;

Antiulcer dihydrodibenzocycloheptyliden-ethylamine derivatives and

A dihydrodibenzocycloheptyliden-ethyl-piperazine derivative of the general formula: ##STR1## in which, R=--CH.dbd.CH.sub.2 ; --CH.sub.2 OH; --COOH; --CO.sub.2 C.sub.2 H.sub.5 ; --CH.dbd.CH--CO.sub.2 CH.sub.3 ; --CH.dbd.CH--CO.sub.2 CH.sub.3, --C.sub.6 H.sub.5, ##STR2## or pharmaceutically acceptable salts thereof, are disclosed. The compounds of the invention are useful in pharmaceutical compositions for the treatment of pathologies responsive to vasodilatory agents.

Vasodilatory dihydrodibenzocycloheptyliden-ethyl piperazine derivatives

A new compound derived from p-chlorophenoxyacetic acid, the p-chlorophenocetate of 1-aminoadamantine-2-ethanol of the following structural formula I: ##STR1## as well as its pharmaceutically acceptable salts, possessing properties for the treatment of various pathological conditions of the central nervous system. Also disclosed are its method of preparation; pharmaceutical compositions containing the said compounds; and the treatment of various pathological conditions of the central nervous system with the use of the said compositions.

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Barcelona, Spain

Romeo R Andreoli