Eniricerche S.p.a.

Sclavo Spa

Snamprogetti

Ente Nazionale Idrocarburi

Romano Di Trapani

Antonio S Verdini

Antonello Pessi

Walter Marconi

Massimo Pinori

Fabio Bonelli

Franco Cardinali

Diana Boraschi

Stefano Censini

The present invention refers to a new class of malonic acid derivatives of general formula I ##STR1## wherein R.sup.1 and R.sup.2, each independently, represent hydrogen or a carboxyl protecting group, and the residue R corresponds to the side-chain of the amino acids lysine, ornithine, tyrosine, cysteine, asparatic acid and glutamic acid wherein the additional functionalities are suitably protected. The new compounds of the present invention are useful for preparing analogues of biologically active peptides wherein the direction of some amide bonds in which the amino acids lysine, ornithine, tyrosine, cysteine, aspartic acid or glutamic acid are involved, has been reversed.

Malonic acid derivatives and methods for their synthesis

New partially retro-inverted tuftsin analogues of general formula I ##STR1## wherein R represents the side-chain of the amino acids threonine, methionine or leucine

Partially retro-inverted tuftsin analogues, method for the preparation

Synthesis of an analogue of the (5-14) decapeptide of equine angiotensinogen partially retro-inverted at the Phe-Phe bond, of formula: ##STR1## The retro-inverso analogue inhibits renin with high resistance to enzymatic degradation, and can be used in the treatment of renin-dependent hypertension.

Partially retro-inverted decapeptide as a specific renin inhibitor with

A composition for the purification of blood in which impurities of the mercaptan class are present is disclosed, such composition being occluded in fibrous materials and consisting of a polymer functionalized with an organic mercury compound or with an anhydride of an organic acid. As the functionalizing compounds parachloromercury aniline, parachloromercurybenzoic acid and maleic anhydride are preferred.

Biocompatible cellulose triacetate fibres for the purification of blood

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Monterotondo, Italy

Romano Di Trapani