Alberta Research Council Incorporated

Glycomed, Inc.

Isotechnika Inc.

Roman Szweda

Om P Srivastava

Ulrike Spohr

Richard H Smith

Robert M Ippolito

Robert T Foster

Randall W Yatscoff

Ole Hindsgaul

David R Bundle

Kevin R Holme

Minghui Du

Mark D Abel

H Rizk Hanna

Geeta Srivastava

Daniel Trepanier

Frank W Barresi

This invention provides modified rapamycins that have specific monosaccharide(s), oligosaccharide(s), pseudosugar(s) or derivatives thereof attached through a linker to create rapamycin carbohydrate derivatives having enhanced pharmacokinetic and/or pharmacodynamic profiles. For example, administration of the rapamycin carbohydrate derivative results in altered pharmacokinetic profiles and reduced toxicities. Thus, the present invention provides compounds with characteristics that are distinct from other drugs in its class such as rapamycin.

Rapamycin carbohydrate derivatives

Disclosed is the trisaccharide .alpha.-D-Glcp-(1-2)-.alpha.-D-Glcp-(1-3)-.alpha.-D-Glcp and compounds related thereto as well as pharmaceutical compositions thereof.

Modified

Disclosed are novel analogues of kojibiose and pharmaceutical compositions comprising such analogues.

Modified kojibioside analogues

Disclosed are novel oligosaccharide glycosides having mammalian immunosuppressive and tolerogenic properties, pharmaceutical compositions containing such oligosaccharide glycosides and to methods of using such oligosaccharide glycosides to modulate cell-mediated immune responses in a mammal.

Oligosaccharide glycosides having mammalian immunosuppresive and

The present invention is directed to methods of reducing the degree of inflammation arising from a secondary immune response in a mammal due to antigen exposure (challenge) by the administration of valienamine-related disaccharide compounds and the pharmaceutical compositions employed in the method.

Administration of valienamine-related disaccharide compounds in reducing

Modified kojibiosides analogues

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Edmonton, Canada

Roman Szweda