Cytokinetics, Inc.

University of California

Roman Sakowicz

Christophe Beraud

Kenneth Wood

Jeffrey T Finer

Fady Malik

Lawrence S B Goldstein

James Hartman

Christopher Bentley Shumate

Andrew Craven

Ming Yu

Don W Cleveland

Cordula Hopmann

Corey E Nislow

David John Faulkner

Michael S Berdelis

Christine L Blackburn

John Mak

Richard Freedman

Umesh A Patel

Katherine A Davies

Eugeni Vaisberg

Cara Ohashi

Ken Wood

Lawrence Sb Goldstein

The invention provides novel compositions, methods, and uses of hSMMyHC polypeptides and polynucleotides.

Human smooth muscle myosin heavy chain

Described herein are methods which identify candidate agents as binding to a protein or as a modulator of the binding characteristics or biological activity of a protein. Generally, the methods involve the use of ADP or phosphate. The assays can be used in a high throughput system to obviate the cumbersome steps of using gels or radioactive materials.

Compositions and assays utilizing ADP or phosphate for detecting protein modulators

The present invention relates to protein modulators, especially modulators of kinesin bioactivities. The present invention provides methods for screening protein modulators, e.g., kinesin modulators that bind to a region of a kinesin and/or that modulate kinesin bioactivities. The present invention also provide methods and compositions for treatment of disorders mediated by abnormal cellular proliferation activities.

Method for identifying kinesin inhibitors

The invention provides isolated nucleic acid and amino acid sequences ofCENP-E (XCENP-E), antibodies to XCENP-E, methods of screening for CENP-E modulators using biologically active CENP-E, and kits for screening for CENP-E modulators.

Plus end-directed microtubule motor required for chromosome congression

The invention provides isolated nucleic acid and amino acid sequences of HsKip3, antibodies to HsKip3, methods of screening for HsKip3a modulators using biologically active HsKip3, and kits for screening for HsKip3a modulators.

Motor proteins and methods for their use

The present invention provides high throughput screening methods for characterizing compounds that modulate the biological activity of a biochemically functional sarcomere. Compounds characterized by such methods are useful for treating congestive heart failure.

Methods for treating congestive heart failure

The invention provides isolated nucleic acid and amino acid sequences of Xenopus CENP-E (XCENP-E), antibodies to XCENP-E, methods of screening for CENP-E modulators using biologically active CENP-E, and kits for screening for CENP-E modulators.

Methods for screening and therapeutic applications of kinesin modulators

The invention provides isolated nucleic acid and amino acid sequences of TL-&ggr;, antibodies to TL-&ggr;, methods of screening for TL-&ggr; modulators using biologically active TL-&ggr;, and kits for screening for TL-&ggr; modulators.

Identification and expression of a novel kinesin motor protein

This invention provides novel compounds derived from a marine sponge, Adocia sp., that specifically modulat kinesin activity by targeting the kinesin motor domain and mimicking the activity a microtubule. The compounds act as potent anti-mitogens are useful in a wide variety of in vitro and in vivo applications.

Kinesin motor modulators derived from the marine sponge Adocia

The invention provides isolated nucleic acid and amino acid sequences of TL- , antibodies to TL- , methods of screening for TL- modulating using biologically active TL- , and kits for screening for TL- modulators.

Thermomyces lanuginosus kinesin motor protein and methods of screening for modulators of kinesin proteins

Methods for purifying actin are provided. The methods generally involve the addition of a magnesium salt in a sufficient quantity, whereby G-actin polymerizes to form actin paracrystals, which can be recovered as a purified form of actin.

Growing community of inventors

Foster City, CA, United States of America

Roman Sakowicz