Lilly Icos LLC

Smithkline Beecham Corporation

Romain Luc Gosmini

Jason Scott Sawyer

Mark W Orme

Agnes Bombrun

Alain Claude-Marie Daugan

Lisa M Schultze

Michael Lawrence Sierra

Nerina Dodic

Bernard Andre Dumaitre

Françoise Jeanne Gellibert

Raymond F Brown

Anne Bouillot

Compounds of the general structural formulaand use of the compounds and salts and solvates thereof, as therapeutic agents.

Carboline derivatives

Selective inhibitors of cGMP-specific PDE, and use of the compounds and salts and solvates thereof as therapeutic agents, are disclosed.

Carboline derivatives as PDE5 inhibitors

A compound of formula (I) and pharmaceutically acceptable salts, solvates and hydrolysable esters thereofWherein Xrepresents NH, NCHor O; Rrepresents Calkyl, (optionally substituted by one or more halogens), &#x2014;Calkyl-5 membered heteroaryl, Calkyl-(O)-phenyl, wherein n is 0 or 1, with the proviso that when Rand Rare methyl, Rand Rare H, Ris H, then Rcannot be CHor CF.

Thiazole or oxazole derivatives which are useful in the treatment of cardiovascular and related diseases

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Les Ulis, France

Romain Luc Gosmini