Oregon Health & Science University

The United States Government As Represented by the Department of Veterans Affairs

Avantbio Corporation

University of South Florida

Interlab Inc.

Medicines for Malaria Venture

Other

The United States of America

Rolf W Winter

Michael Kevin Riscoe

David J Hinrichs

Jane Xu Kelly

Aaron Nilsen

Martin J Smilkstein

Sovitj Pou

Dennis Edward Kyle

Roman Manetsch

David Lawrence Flanigan

Richard Matthew Cross

Rozalia Dodean

Yuexin Li

Galen Miley

Jeremy Burrows

Andrii Monastyrskyi

A laboratory flask for use in association with a laboratory heating block, having: a flask body, wherein the flask body includes an upper portion, a lower portion, and a sidewall, wherein the sidewall of the flask body includes an inner surface, and an outer surface; a neck, wherein the neck includes an upper portion, a lower portion, and a sidewall, wherein the sidewall of the neck includes an inner surface, and an outer surface, and wherein the neck emanates contiguously from the flask body; and a reservoir, wherein the reservoir includes an upper portion, a lower portion, a bottom wall, and a sidewall, wherein the sidewall of the reservoir includes an inner surface, and an outer surface, and wherein the reservoir is adapted for releasable securement within a laboratory heating block.

Laboratory glassware and associated methods for using the same

Described herein are methods for the bromine-facilitated synthesis of fluoro-sulfur compounds, that include SF, SFCl, SFBr and SF. The methods described herein generally require lower temperature and pressure, produce higher yields, require less time, do not use corrosive or costly reactants and solvents that are commonly used in the synthesis of the fluoro-sulfur compounds, and do not produce deleterious waste products when compared to previously-used methods.

Bromine-facilitated synthesis of fluoro-sulfur compounds

Disclosed are derivative compounds of ELQ-300 that include an ester at position 4. These compounds have enhanced properties relative to ELQ-300. Also disclosed are pharmaceutical compositions comprising the compounds and methods of treating and preventing malaria infections involving administering the pharmaceutical compositions to the subject.

Quinolone-3-diarylethers

Bromine facilitated synthesis of fluoro-sulfur compounds

Compounds, compositions and methods useful for treating infectious diseases are provided. In particular, 3-aryl quinoline compounds, their synthesis, pharmaceutical compositions thereof and methods of treating infectious diseases such as malaria, are disclosed.

Compounds, compositions and associated methods comprising 3-aryl quinolines

(A1) A class of acridone compounds has been discovered that exhibits chemosensitizing and antiparasitic activity. Described herein are pharmaceutical compositions and methods for their use to treat parasitic infections, such as malaria and toxoplasmosis, and to sensitize resistant cells, such as multidrug resistant cells to other therapeutic agents. The pharmaceutical compositions and methods may also be used to treat and/or prevent psychotic diseases such as schizophrenia.

Acridone compounds

Compounds having antiparasitic or anti-infectious activity

A class of acridone compounds has been discovered that exhibits chemosensitizing and antiparasitic activity. Described herein are pharmaceutical compositions and methods for their use to treat parasitic infections, such as malaria and toxoplasmosis, and to sensitize resistant cells, such as multidrug resistant cells to other therapeutic agents. The pharmaceutical compositions and methods may also be used to treat and/or prevent psychotic diseases such as schizophrenia.

Growing community of inventors

Portland, OR, United States of America

Rolf W Winter