Bayer Aktiengesellschaft

Bayer Healthcare LLC

Bayer Technology Services Gmbh

Talecris Biotherapeutics, Inc.

Rolf Treckmann

Jurgen Kirsch

Gunther Weymans

Hanns-Ingolf Paul

Wolfgang Herrig

Klaus Kaiser

Jurgen Heuser

Jörg Kauling

Hans-Jürgen Henzler

Joerg Kauling

Klaus Elgeti

Cynthia J Galloway

Dirk Havekost

Hans-Juergen Henzler

Stephan Kirchner

Kathryn Remington

Richard Pasquinelli

The present invention relates to a method for precipitation of peptide where the mixing step of the peptide with the precipitation aid and the precipitation itself are specially separated.

Device and method for precipitation of peptides

A method of inactivating microorganisms such as viruses within a fluid such as a biological fluid is disclosed. The method includes the steps of providing a UV reactor, which may take the form of an elongated generally annular reaction chamber surrounding at least one elongated UV lamp, moving the fluid within the reaction chamber in a primary flow directed along the length of the UV lamp, and inducing a circulating secondary flow within the fluid with the secondary flow being superimposed on the primary flow. As the fluid moves through the reaction chamber in the primary flow, it is circulated repeatedly toward and away from the UV lamp in the circulating secondary flow to provide uniform and controllable exposure of the entire volume of fluid to ultraviolet radiation. Microorganisms such as viruses are thus inactivated while desirable components in the fluid, such as proteins, are preserved without the use of a free radical scavenger.

Method of inactivating microorganisms in a fluid using ultraviolet radiation

According to the invention, a special process for isolating polycarbonate from methylene chloride at temperatures of 30.degree. to 80.degree. C. in the form of a powder with residual solvent contents below 5% by weight is started up as a continuous process by starting up in a two-component nozzle, in which CO.sub.2 -containing fluid and the polymer solution are continuously combined, with a large excess of CO.sub.2 and then allowing the polycarbonate/methylene chloride/CO.sub.2 fluid system to pass through the gel-forming range of the polycarbonate/methylene chloride/CO.sub.2 phase diagram with continuous reduction of the CO.sub.2 throughput to a ratio of CO.sub.2 to organic solution of 4:1 to 2:1. The process started up in this way has a particularly long useful life.

Isolation of polycarbonate with carbon dioxide

A process for isolating polymers from their solvents by addition of fluids containing carbon dioxide at temperatures of 30.degree. to 280.degree. C. and under pressures of 1 to 1,000 bar is disclosed. The process is characterized in that the concentration of the polymers in their solvents is between 5% and 80% by weight and the fluid containing carbon dioxide consists of at least 50% by weight carbon dioxide.

Process for isolating polymers from their solvents using liquids

A continuous process for the isolation of polycarbonates from a solution of polycarbonate in methylene chloride at temperatures of 30.degree. to 80.degree. C. is disclosed. The process which yields polycarbonate in powder form having residual solvent content of less than 5% by weight, is characterized in that it entails the following steps:

Process for isolating polycarbonates with CO.sub.2 under pressure

Growing community of inventors

Cologne, Germany

Rolf Treckmann