Boehringer Ingelheim International Gmbh

Sanofi-A Ventis Deutschland Gmbh

Boehringer Ingelheim Pharma Gmbh & Co Kg

Rolf-Stefan Brickl

Richard John Varsolona

Zeren Wang

Zhi-Hui Lu

Thomas Friedl

Danping Li

Shirlynn Chen

Chitra Telang

Jihchin Chung

Herrad-Odilia Krenkel

Mayur Suryakant Dudhedia

Siddharthya Mujumdar

Jürgen Schraivogel

Juergen Schraivogel

Thomas Haegele

The present invention relates to solid preparations containing ambroxol which are obtainable by melt extrusion of the mixture consisting of a) 30 to 80% by weight of ambroxol hydrochloride, b) 2 to 68% by weight of at least one hydrogenated vegetable oil, c) 2 to 68% by weight of at least one mixture containing fatty acid ester and/or hydroxy fatty acid ester and d) 0 to 66% by weight of one or more pharmaceutical adjuvants, based in each case on the total amount of the preparation and its use for secretolytic treatment in acute and chronic bronchopulmonary diseases.

Solid ambroxol-containing preparation

An extended release pellet comprising an active ingredient selected from pramipexole and the pharmaceutically acceptable salts thereof, and at least one release-modifying excipient.

Extended release pellet formulation containing pramipexole or a pharmaceutically acceptable salt thereof

This invention relates to novel sodium salt forms of the following Compound (1), and methods for the preparation thereof, pharmaceutical compositions thereof, and their use in the treatment of Hepatitis C Viral (HCV) infection: 

Solid state forms of a potent HCV inhibitor

A dosing device for dispensing small-particulate pharmaceutical preparations has at least one chamber for receiving a larger amount of the preparation and a dosing unit. A rotary valve has at least one dosing chamber for receiving a defined dose of the preparation. The dosing chamber is moveable between a filling position and a dispensing position. The rotary valve rotates about a substantially horizontal axis, and has an adjustment device for setting the volume in the dosing chamber and a twisting device. The twisting device constitutes the actuator for the adjustment device. The device is made of a plastic material carefully selected to assure that no softening agents or other volatile components will be released, which prevents drug contamination.

Dosing device for medicaments

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Warthausen, Germany

Rolf-Stefan Brickl