Ge Healthcare As

Nycomed Imaging As

Rolf Servin

Mikkel Jacob Thaning

Lars-Goran Wistrand

Sven Goran Andersson

Klaes Golman

Haukur Johannesson

Finn Radner

Jan Henrik Ardenkjaer-Larsen

Jan Wolber

Jan-Henrik Ardenkjaer-Larsen

Anna Rydbeck

Lennart Hansson

Torsten Almen

Graham John Cotton

Georg Hansson

Frode Rise

Herbert Baumann

Christian Gloegaard

Hangkan Wikstrom

Mikkel Jo Slashedrgensen

Arne Aabye

Oskar H E Axelsson

Mark Howard

Anna Rydbeek

Maurice Goldman

Mathilde H Lerche

Peter Michelsen

Mikkel Thaning

The invention relates to a method of dynamic nuclear polarisation (DNP) using a combination of a trityl radical and a paramagnetic metal ion as the polarising agent leading to enhanced levels of polarisation in the sample to be polarised and to compositions and polarising agents for use in the method.

Method of dynamic nuclear polarisation (DNP)

The invention relates to an improved method of dynamic nuclear polarisation (DNP) of carboxylic acids and to compounds and compositions for use in the method.

Method of dynamic nuclear polarisation (DNP) and compounds and compositions for use in the method

The present invention relates to a method for the production of hyperpolarizedXe and to a method for the production of a contrast agent.

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The invention relates to NMR-based methods comprising hyperpolarised ligands or targets for use in NMR-based assays.

NMR-based methods for detecting ligands, where the ligand or target are hyperpolarized and the NMR-spectrum is compared with a reference spectrum of the ligand or target

The present invention relates to methods of performing Nuclear Magnetic Resonance (NMR) spectroscopy adapted for a hyperpolarized sample. The methods comprise the steps of hyperpolarizing a sample using DNP, wherein at least a portion of the NMR active nuclei receives hyperpolarization; performing NMR spectroscopy on the sample with the use of sequences of rf-pulses, wherein the pulse sequences comprises at least two rf-pulses, either on the same nuclei or on different nuclei, and wherein the pulse sequence is adapted for a hyperpolarized sample; and analyzing at least two of the NMR spectra to obtain a characterization of the sample, or to obtain an interim result to be used in the NMR spectroscopy step.

Multidimensional NMR spectroscopy of a hyperpolarized sample

The present invention relates to devices and method for dissolving solid polarised material while retaining a high level of polarisation. In an embodiment of the present invention a material is polarised in a strong magnetic field in a cryostatand then brought into solution while still inside the cryostat

Methods and devices configured for dissolving hyperpolarised solid material with a solvent within a cryostat for NMR analyses

The present invention relates to certain novel triaryl methyl free radicals and their use as image enhancing agents in magnetic resonance imaging (MRI) as well as to contrast media containing such radicals and to the use of such radicals and their non-radical precursors in the manufacture of MRI contrast media.

Free radicals comprising benzodithiole derivatives

The present invention relates to a method of generating an electron spin resonance enhanced magnetic resonance image of a sample which comprises introducing into the sample a magnetic resonance signal enhancing amount of a free radical and generating an enhanced electron spin resonance image of the sample. The method comprises using as the free radical an inert triarylmethyl free radical, wherein each aryl moiety of said triarylmethyl radical, which may be identical or different, comprises an optionally substituted 6-membered carbocyclic or thienyl ring. The invention also relates to the use of trityls in ESR imaging.

Use of free radicals in ESR and ESREMR imaging

Free Radicals

The invention provides novel persistent free radicals useful in Overhauser MRI being triarylmethyl radicals having as at least one aryl group a group of formula ##STR1## (wherein each X which may be the same or different is an oxygen or sulphur atom or a group CO or S(O).sub.n, (where n is 1 to 3) with the proviso that at least one group X is a sulphur atom or a S(O).sub.n group; R.sup.1 is a hydrogen atom or group of formula --M, --XM, --X--Ar.sup.2, or --Ar.sup.2 where M is a water solubilizing group, and Ar.sup.2 represents a 5-10 membered aromatic ring optionally substituted by a water solubilizing group M; and each of the groups R.sup.7, which may be the same or different, is a hydrogen atom, or a hydrocarbon group or a water solubilizing group M, or two groups R.sup.7 together with the atom to which they are bound represent a carbonyl group or a 5 to 8 membered cycloalkylidene, mono- or di-oxacycloalkylidene, mono- or di-azacycloalkylidene or mono- or di-thiacycloalkylidene group optionally with the ring attachment carbon replaced by a silicon atom, and R.sup.7 where it is other than hydrogen, is optionally substituted by a hydroxyl group, an optionally alkoxylated, optionally hydroxylated acyloxy or alkyl group or a water solubilizing group M)). The novel radicals have good stability, long relaxation times and good relaxivity.

Free radicals

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Malmo, Sweden

Rolf Servin