Alcon Laboratories, Inc.

Stamicarbon B.v.

Amics Ag

Rolf Schafer

Doris Schafer

Nissanke L Dassanayake

Ronald L Schlitzer

Hans Hitz

Jacob K Smid

Johan G Aalbers

Werner Schafer

A contact lens cleaning solution containing an enzyme having proteolytic activity and a surfactant, and optionally also a chelating agent and urea, and a method of cleaning contact lenses utilizing this solution are described. The solution and method effectively remove deposits of proteinaceous material, mucins, lipids and calcium located either on or beneath the surface of the lens.

Use of pluronic surfactant to enhance the cleaning effect of pancreatin

Certain alkenyl diamines, the use of same for disinfecting and cleaning contact lenses and preserving ophthalmic products, and associated ophthalmic compositions are described.

Use of diamines in ophthalmic compositions

Use of diamines to disinfect and clean contact lenses

Use of nonionic surfactant to enhance the cleaning effect of pancreatin

From organs of embryonic mammalia a new extract of active ingredients is recovered which extract can be used for controlling a reduced blood flow through periperhic organs and through the brain and which extract can be also used for controlling acne vulgaris. The corresponding extracts are used as active ingredients of corresponding pharmaceutical preparations. The new pharmaceutically active extract is prepared according to a process in which polar substances having a molecular weight below 5000 are isolated from the embryonic mammalian organs avoiding any degradation of substances having a higher molecular weight. The finely divided embryonic mammalian organs are extracted with a mixture of water and a water soluble organic solvent which contains nor more than 30 vol.-% of water at an about neutral pH value for stirring and refluxing. The resulting solution is then submitted to a predetermined sequence of further drying steps, heating steps and cooling steps, and finally to a filtration with an ultramembrane filter in order to remove any substances having a molecular weight of about 5000. The extract is then finally concentrated under vacuum to yield a liquid concentrate or a dry residue.

Extracts of embryonic organs, process for their preparation and

Novel surfactant compounds are provided of the formula R--CO--NH--(C.sub.2 H.sub.4 O).sub.n --CH.sub.2 COOH, wherein R--CO-- is the residue of at least one aliphatic carboxylic acid of 6-22 carbon atoms and n represents a number having an average of 2-10, as well as their salts with alkali metals, ammonium and amines. These compounds possess not only a low primary toxicity, but also a low secondary toxicity for the skin, and accordingly they are especially useful in cosmetic compositions, compositions for non-automatic dishwashing and laundering compositions for the fine laundry.

Novel polyether carboxylic acid derivatives, as well as their uses

Nontoxic, aqueous, contact lens cleaning compositions containing a weakly anionic surfactant, and optionally also a chelating agent, urea and/or a source of hydrated protons, and methods of chemically removing protein, lipid and calcium deposits from contact lens utilizing these compositions are described.

Method of cleaning contact lens using compositions containing polyether

A sustained release drug delivery system suitable for ophthalmic use is described. The delivery system utilizes a cationic polymer (polyquat) to deliver a drug residue. The drug residue delivered may comprise an anionic drug or a drug-carrier complex.

Sustained release drug delivery system utilizing bioadhesive polymers

Solution and method for removing inorganic and organic deposits from

A nontoxic, aqueous, contact lens cleaning solution containing a mixture which includes a nonionic or weakly anionic surfactant, a chelating agent, a source of hydrated protons, and optionally also urea; and a method of chemically removing protein, lipid and calcium deposits from contact lens utilizing this solution are described.

Solution and method for removing protein, lipid, and calcium deposits

The improved polymeric hydrogel suitable for use in forming soft contact lenses is described. The hydrogel is improved by means of its resistance to the formation of calcium, lipid and protein deposits thereon. This resistance is achieved by means of covalent modification of the hydrogel with a surfactant.

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Arisdorf, Switzerland

Rolf Schafer