Hoechst Aktiengesellschaft

Rolf-Ortwin Weber

Ulrich Gebert

Alfons Soder

Istvan Boksay

Josef Musil

Hiristo Anagnostopulos

Klaus Perrey

Wolfrad Von Rechenberg

Volkher Bollmann

A compound having the general formula or an acid addition salt thereof ##STR1## in which formula R.sub.1 is selected from the group consisting of

Cyclic diamine derivatives

Pharmaceutical compositions containing N-alkyl-N-(nuclearly-substituted)

A compound of the formula ##STR1## or its acid addition salt with a physiologically compatible acid, a process for its preparation by a reaction selected from the group consisting of

N,N'-Disubstituted piperazine derivative

Compounds of general formula ##STR1## are disclosed wherein appropriate substituents for R.sup.1, R.sup.2 to R.sup.5, R.sup.6, A, Q, X, and Z are defined for these novel hexahydropyrimidines. Procedures for the preparation of these compounds are also given. Because of the highly effective serotonin antagonistic activity in combination with a strong inhibiting effect on thrombocyte aggregation and good compatibility these compounds are effective in treating migraine. Additionally, the compounds also exhibit an anti-histamine activity, cause an increase in erythrocyte fluidity, a psychotropic activity, a weak bradykinin antagonism and hypotensive effects.

Aromatic piperazinyl substituted dihydrouracils

A physiologically-acceptable compound of one of the formulae ##STR1## wherein R.sup.1 is a member selected from the group consisting of (a) a 6-membered heteroaromatic ring with up to two ring hetero atoms selected from the group consisting of O, N and S, at most one of which is different from nitrogen, and (b) an alkyl group containing from 1 to 4 carbon atoms and substituted by such a heteroaromatic ring;

Novel derivatives of imidazole and pharmaceutical compositions

A compound of one of formulae (I) and (II) (of formula sheet) wherein

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Wiesbaden, Germany

Rolf-Ortwin Weber