Astra Aktiebolag

Medivir Ab

Rolf Noreen

Daniel Dungan Sohn

Svante Bertil Ross

Seth-Olov Thorberg

Lars George Johansson

Eva Maria Hammarberg

Lars-Gunnar Larsson

Lucy Anna Renyi

Bjorn Eric Svensson

John Michael Morin, Jr

Robert J Ternansky

Peter Tomas Lind

Karl N Johansson

Christer Sahlberg

Per Engelhardt

Marita Hogberg

Sal O Gronowitz

S Christer Sahlberg

Tomas Lind

Hans C Malmberg

Peter Thomas Lind

Antivirals

N-arylalkyl-N-heteroarylurea and guandine compounds and methods of

Treatment of AIDS, inhibition of the replication of HIV and related viruses thereof, and formulations using thiourea derivative compounds or salts thereof is disclosed. Also disclosed are novel thiourea derivative compounds.

Compounds and methods for inhibition of HIV and related viruses

3-amino-5-carbonylchromans, as well as enantiomers and salts thereof are disclosed. Pharmaceutical compositions containing the compounds as active ingredients are also disclosed. The compounds are useful in the treatment of 5-hydroxytryptamine-mediated disorders of the central nervous system.

Chroman derivatives

A method is disclosed for the treatment of anxiety by the administration of 3-amino-5-carbamoyl-chromans and 8-fluoro-3-amino-5-carbamoylchromans or enantiomers or salts thereof.

Method for the treatment of anxiety

Compounds of the formula ##STR1## are disclosed. These compounds are employed as intermediates in the synthesis of aminochroman compounds useful in the treatment of CNS disorders.

Intermediates in the synthesis of chroman derivatives

A method is disclosed for the treatment of depression by the administration of 3-amino-5-carbamoylchromans and 8-fluoro-3-amino-5-carbamoylchromans or enantiomers or salts thereof.

Method for the treatment of depression

3-amino-5-aryl- and 5-heteroarylchromans, as well as enantiomers and salts thereof are disclosed. Pharmaceutical compositions containing the compounds as active ingredients are also disclosed. The compounds are useful in the treatment of 5-hydroxytryptamine-mediated disorders of the central nervous system.

A method is disclosed for the treatment of migraine by the administration of 3-amino-5-carbamoyl-chromans and 8-fluoro-3-amino-5-carbamoylchromans or enantiomers or salts thereof.

Method for the treatment of migraine

Method for inhibition of HIV related viruses

The present invention is directed to compounds of formula (I), ##STR1## wherein R.sup.1 is OH, NH.sub.2 ; R.sup.2 is a heteroaromatic or aromatic substituent; R.sup.3 is H, OH, F, OCH.sub.3 ; R.sup.4 is H, F, OH or an ether or ester residue thereof, OCH.sub.3, CN, C.dbd.CH, N.sub.3 ; R.sup.5 is OH or an ether or ester residue thereof including mono, di- and triphosphate esters (.alpha.), wherein n is 0 or 1 and M is hydrogen or a pharmaceutically acceptable counterion such as sodium, potassium, ammonium or alkylammonium; and pharmaceutically acceptable salts thereof; and pharmaceutical compositions comprising said compounds can be used for therapeutic treatment of virus infections.

5-substituted pyrimidine nucleosides and nucleotides

Growing community of inventors

Huddinge, Sweden

Rolf Noreen