Helmholtz-zentrum Fur Infektionsforschung Gmbh

Sanofi

Universitaet Des Saarlandes

Atlas Elektronik Gmbh

Helmholtz-zentrum Fuer Infektionsforschung Gmbh

Universität Des Saarlandes

Ursapharm Arzneimittel Gmbh

Helmholtz-zentrum Für

Infektionsforschung Gmbh

Acies Bio D.o.o.

Leibniz-institut Für Naturstoff-forschung Und Infektionsbiologie E.v. -hans-knöll-institut- (hki)

Rolf Müller

Jennifer Herrmann

Andreas Kirschning

Kathrin Mohr

Heinrich Steinmetz

Rolf Wolfgang Hartmann

Klaus Gerth

Mostafa Hamed

Maria Moreno

Liang Liang Wang

Walid A M Elgaher

Sascha Baumann

Franziska Gille

Ritesh Raju

Stephan Hüttel

Mark Broenstrup

Silke Wenzel

Walid A Elgaher

Joachim Wink

Heiko Schmidt

Luigi Toti

Rolf Jansen

Wulf Dirk Leuschner

Hans-Martin Dahse

Johann Gassenhuber

Marc Stadler

Ronald O Garcia

Klaus Eschmann

Claus Lattemann

Ernst Roemer

Markus Nett

Mark Brönstrup

Hans-Peter Prochnow

Stephan Huettel

Shwan Rachid

Katja Gemperlein

Irene Wagner-Döbler

Katrin Jungmann-Sahner

Stefan Werner

Kirsten Harmrols

Emilia Oueis

Anastasia Andreas

Antione Abou Fayad

Mark Stadler

Dominik Pistorius

Alexander Brachmann

Chengzhang Fu

Wolfgang Dorsch

Claudia Koenig

Jannik Donner

Sebastian Schieferdecker

Tina Binz

Giambattista Testolin

Carsten Volz

Yi Chai

Steffen Bernecker

Michael Reck

Charlotte Grandclaudon

Angelika Ullrich

Tim Mollner

Uli Kazmaier

Antje Ritter

Nora Luniak

Jonas Ammermann

Nestor Zaburannyi

Michael Wolling

Stephan Huttel

Chantal Bader

Antoine Abou Fayad

Maja Remskar

Jesko KÖHNKE

Asfandyar Sikandar

Walid A M Elhaher

Sabrina Karwehl

Jan Henning Sahner

Hilda Sucipto

Matthias Groh

Frank Surup

Konrad Viehrig

Ronald Garcia

Tadeja Lukezic

The present invention relates to novel chlorotonil derivatives of formula (I) and the use thereof for the treatment or prophylaxis of bacterial infections and malaria. 

Chlorotonil derivatives

Chemical compounds are provided that are useful in the treatment of diseases associated with an activity of a 5,10-methylenyltetrahydrofolate cyclohydrolase/5,10-methylene tetrahydrofolate dehydrogenase enzyme in pathological eukaryotic cells. In particular, compounds that exhibit inhibitory activity upon 5,10-methylenyltetrahydrofolate cyclohydrolase/5,10-methylene tetrahydrofolate dehydrogenase enzymes and their use in the treatment of cancer and/or parasitic diseases are provided.

Carolacton and derivatives thereof for use in the treatment of cell proliferation disorders

The present invention provides cystobactamides of formula (I): R&#x2014;Ar-L-Ar-L-Ar-L-Ar-L-Ar&#x2014;Rand the use thereof for the treatment or prophylaxis of bacterial infections.

Crystobactamides

The present invention relates to novel derivatives of cystobactamides of formula (Ib) and the use thereof for the treatment or prophylaxis of bacterial infections. 

Cystobactamide derivatives

The present invention provides cystobactamides of formula (I) and the use thereof for the treatment or prophylaxis of bacterial infections.R&#x2014;Ar-L-Ar-L-Ar-L-Ar-L-Ar&#x2014;R&#x2003;&#x2003;(I):

Cystobactamides

The present invention provides a tomaymycin biosynthetic gene cluster ofspecies FH6421, and its use for producing 11-de-O-methyltomaymycin.

Method for producing recombinant 11-de-O-methyltomaymycin

The present invention provides a method for the treatment or prophylaxis of bacterial infections by administering to a subject in need thereof an effective amount of a compound of formula. 

The present invention provides a method for producing &#x3c9;-3 polyunsaturated fatty acids by culturing specific myxobacterial stains and myxobacterial strains suitable for said method.

Production of omega-3 fatty acids by myxobacteria

The invention relates to a monitoring system for monitoring a watercraft or several watercrafts, having an identification device and a first hydrophone, which is configured such that acoustic signals that are emitted by watercrafts are determined as underwater sound information therein, whereby the identification device has a first memory for storing the underwater sound information and a second memory for storing watercraft information, whereby the first and second memories are interconnected, characterized in that the first hydrophone is arranged in a stationary and fixed manner.

Monitoring system for monitoring a watercraft or several watercrafts as well as a process for verifying a watercraft or several watercrafts

The present invention refers to the gene cluster and genes comprised by the gene cluster which are involved in the biosynthesis of griselimycin and methylgriselimycin and to the use of the gene cluster, genes comprised thereby and proteins encoded thereby for the production of antibiotic agents.

Gene cluster for biosynthesis of griselimycin and methylgriselimycin

The invention relates to bioactive pre-tubulysin derivatives, their preparation and pharmacological use.

Bioactive pre-tubulysins and use thereof

The present invention pertains in general to Bromelain and particularly to the different active compounds contained in this complex mixture of proteins. The present invention provides recombinant expressed cysteine proteases, which are found in Bromelain. It has been found that the method for expression of the recombinant proteins is superior to the purification from Bromelain itself.

Recombinant preparation of selected bromelain fractions

The invention provides the amino acid sequences comprised in or constituting the synthetic pathway enzymes participating in the production of Argyrins, as well as the nucleic acid sequences encoding the synthetic pathway enzymes participating in the production of Argyrins, as well as genetically manipulated micro-organisms containing nucleic acid sequences encoding the synthetic pathway enzymes for the production of Argyrins, e.g. for inserting one or more of these coding sequences, mutating in a targeted manner one or more of these nucleic acid sequences, in a wild type producer micro-organism or in a heterologous micro-organism, for the production of Argyrins.

Synthetic pathway enzymes for the production of argyrins

Growing community of inventors

Blieskastel, Germany

Rolf Müller