Aventis Pharma Deutschland, Gmbh

Hoechst Aktiengesellschaft

Affitech Research As

Hoechst Aktiengesellschaft Ag

Vectron Therapeutics Ag

Wolff Walrode Ag

He Hoechst Aktiengesellschaft

Rolf Mueller

Hans-Harald Sedlacek

Roland Kontermann

Hans Heinrich Heidtmann

Horst Kromer

Heinz-Werner Rohrka

Klaus-Heinrich Seifart

Kathrin Koerner

Walter H Alban

Reinhard Luehrmann

Klaus-Juergen Hiltmann

Dirk Nettelbeck

Lothar Sieben

Wolfgang Funk

Wolff Graulich

Joerk Zwicker

The present invention relates to a single-chain, multiple antigen-binding molecule with diverse variable domains of a heavy and of a light chain of an immunoglobulin, which are connected in the form of a VH-VL construct, which are in turn connected together via a peptide, and to the preparation and use thereof as pharmaceutical or diagnostic aid.

Single-chain multiple antigen-binding molecule, its preparation and use

The invention relates to a nucleic acid construct for expressing an active substance which is activated by an enzyme which is released from mammalian cells, which construct comprises the following components: a) at least one promoter element, b) at least one DNA sequence which encodes an active compound (protein B), c) a least one DNA sequence which encodes an amino acid sequence (part structure C) which can be cleaved specifically by an enzyme which is released from a mammalian cell, and d) at least one DNA sequence which encodes a peptide or protein (part structure D) which is bound to the active compound (protein B) by way of the cleavable amino acid sequence (part structure C) and inhibits the activity of the active compound (protein B), and also to the use of the nucleic acid construct for preparing a drug for treating diseases.

Nucleic acid construct for expressing active substances which can be activated by proteases, and preparation and use

Nucleic acid constructs containing hybrid promoters for use in gene therapy and genetic manipulation. The invention relates to a nucleic acid construct for the precise, regulated expression of genes in host cells, which construct exhibits at least one mutation which inhibits the proper expression of the expressed gene and exhibits at least one additional second mutation which relieves the inhibition due to the first mutation, to an isolated cell which harbors the nucleic acid construct, and to the use of the nucleic acid construct for preparing pharmaceuticals and for treating diseases with excessive cell proliferation.

Nucleic acid constructs containing hybrid promoters

Self-enhancing, pharmacologically controllable expression systems

Nucleic acid constructs for expressing an effector gene, with the nucleic acid construct comprising a promoter I (component a) which controls the expression of a transcription factor gene (component b), a transcription factor gene (component b), a promoter II (component c) to which the gene product of the transcription factor gene binds and which controls the expression of an effector gene (component d), and effector gene (component d), wherein the activity of the gene product of the transcription factor gene depends on one or more cellular regulatory proteins which bind to this gene product and affect its activity, and isolated cells containing the nucleic acid constructs, can be used for preparing a drug for treating diseases and in methods of treating diseases.

Oncogene- or virus-controlled expression systems

Nucleic acid constructs are disclosed which possess a nuclear retention signal which is linked, downstream in the reading direction, to a transgene. The nuclear retention signal can regulate the presence of the transcription product in the cell nucleus or else the intracellular transport of the transcription product.

Nucleic acid constructs containing genes encoding transport signals

The promoter of the human endoglin gene, parts thereof, and compositions containing these are useful for high level control of gene expression, particularly in endothelial cells. The promoter, and promoter active portions of the promoter are shown to have unexpected activity and are particularly relevant for therapeutic use.

Promoter of the human endoglin gene

The invention relates to a nucleic acid construct for expressing an active substance which is activated by an enzyme which is released from mammalian cells, which construct comprises the following components: a) at least one promoter element, b) at least one DNA sequence which encodes an active compound (protein B) c) a least one DNA sequence which encodes an amino acid sequence (part structure C) which can be cleaved specifically by an enzyme which is released from a mammalian cell, and d) at least one DNA sequence which encodes a peptide or protein (part structure D) which is bound to the active compound (protein B) by way of the cleavable amino acid sequence (part structure C) and inhibits the activity of the active compound (protein B), and also to the use of the nucleic acid construct for preparing a drug for treating diseases.

Nucleic acid construct for expressing active substances which can be

The invention provides the promoter of the cdc25B gene, a process for finding cdc25B promoters and methods for using the promoters for preparing a pharmaceutical.

Promoter of the cdc25B gene, its preparation and use

Nucleic acid constructs comprising an activator sequence, a promoter module, and a structural gene are disclosed. The promoter module comprises a a CHR region and a nucleic acid sequence that binds a protein of the E2F family. These constructs are used in gene therapy, such as the treatment of disorders characterized by excess cell proliferation.

Nucleic acid constructs for the cell cycle-regulated expression of genes

A film for packaging sliced foodstuffs, such as, for example cheese slices, is wound around the foodstuff in the form of a tube lying flat and completely encloses the foodstuff, the two edge zones on the longitudinal axes of the film overlapping and being joined to one another by a full-surface or partial heat-sealable coating. The film comprises a monolayer or coextruded multilayer, in each case biaxially stretched and heat-fixed, film, which has full-surface or partial peelable heat-sealable coating and contains a water-repellant additive component mixture.

Coated film for packaging sliced foodstuffs

Disclosed is a flexible package made of plastic and capable of standing by itself, comprising a generally cylindrically-shaped body, comprised of a flexible plastic film; a first cover part at one end of the cylindrically-shaped body; and a second cover part at the opposite end of the cylindrically-shaped body, wherein the cover parts are bonded to the plastic film by heat-sealing. Also disclosed is a packaged liquid product, in particular a product under gas pressure, and a method for producing the packaged product.

Growing community of inventors

Marburg, Germany

Rolf Mueller