Thia Medica As

Other

Life Science Nutrition As

Pronovo Biopharma Norge As

Rolf Kristian Berge

Andrew David Miller

Michael R Jørgensen

Jon Skorve

Leiv K Sydnes

Jon Songstad

Karsten Kristiansen

The present invention provides a lipid compound comprising at least one non-polar moiety and a polar moiety, wherein each or at least one non-polar moiety is of the formula X&#x2014;Y&#x2014;Z&#x2014;, wherein X is a hydrocarbyl chain, Y is selected from at least one of S, Se, SO, SO, and O, and Z is an optional hydrocarbyl group, wherein the polar moiety is of the formula &#x2014;[C(O)]PHG, wherein PHG is a polar head group, and wherein m is the number of non-polar moieties.

Sulfur-containing phospholipid derivatives

The present invention relates to fatty acid analogues of the general formula R-[x-CH]&#x2014;COORand in particular to a method of treating inflammatory disorder selected from the group consisting of rheumatoid arthritis, systemic vasculitis, systemic lupus erythematosus, systemic sclerosis, dermatomyositis, and polymyositis; comprising administering to a mammal in need thereof, an effective amount of tetradecylthioaceticacid or tetradecylselenoacetic acid; or a pharmaceutically acceptable salt thereof.

Fatty acid analogues for the treatment of inflammatory and autoimmune disorders

The present invention relates to novel fatty acid analogous of the general formula (I): R&#x2014;[x&#x2014;CH]&#x2014;COORwherein Ris: a C-Calkene with one or more double bonds and/or with one or more triple bonds, and/or a C-Calkyne, and/or a C-Calkyl substituted in one or several positions with one or more compounds selected from the group comprising fluoride, chloride, hydroxy, C-Calkoxy, C-Calkylthio, C-Cacyloxy or C-Calkyl, and wherein R2 represents hydrogen or C-Calkyl, and wherein n is an integer from 1 to 12, and wherein i is an odd number and indicates the position relative to COOR, and wherein Xindependent of each other are selected from the group comprising O, S, SO, SO, Se and CH, and with the proviso that at least one of the Xis not CH, and with the proviso that if R1 is an alkye, then the carbon-carbon triple bond is positioned between the (&#x3c9;-1) carbon and the (&#x3c9;-2) carbon, or between the (&#x3c9;-2) carbon and the (&#x3c9;-3) carbon, or between the (&#x3c9;-3) carbon and the (&#x3c9;-4) carbon, a salt, prodrug or complex thereof, which can be used for the treatment and/or prevention of syndrome X, obesity, hypertension, fatty liver, diabetes, hyperglycaemia, hyperinsulinemia and stenosis. Further, the invention relates to a nutritional composition comprising said fatty acid analogues, and a method for reducing the total weight, or the amount of adipose tissue in an animal.

Fatty acids analogous

The present invention concerns a composition prepared from a combination of non &#x3b2;-oxidizable fatty acid entities and a protein material, and the use of said composition for the preparation of a pharmaceutical or nutritional composition for the prevention and/or treatment of insulin resistance, obesity, diabetes, fatty liver, hypercholesterolemia, dyslipidemia, atherosclerosis, coronary heart disease, thrombosis, stenosis, secondary stenosis, myocardial infarction, stroke, elevated blood pressure, endothelial dysfunction, procoagulant state, polycystic ovary syndrome, the metabolic syndrome, cancer, inflammatory disorders and proliferate skin disorders. An alternative embodiment of the invention includes oil in the composition The present invention also concerns an animal feed prepared from a combination of a protein material and a compound comprising non &#x3b2;-oxidizable fatty acid analogues, the use of said feed for improving the body composition of an animal, and a product produced from said animal.

Composition comprising protein material and compounds comprising non-oxidizable fatty acid entities

A fatty acid analogue of the general formula: R-[x-CH]&#x2014;COOR, wherein Ris: a C-Calkene with one or more double bonds and/or with one or more triple bonds, and/or a C-Calkyne, and/or a C-Calkyl, or a C-Calkyl substituted in one or several positions with one or more compounds selected from the group comprising fluoride, chloride, hydroxy, C-Calkoxy, C-Calkylthio, C-Cacyloxy or C-Calkyl, and wherein R2 represents hydrogen or C-Calkyl, and wherein n is an integer from 1 to 12, and wherein i is an odd number and indicates the position relative to COOR, and wherein Xindependent of each other are selected from the group comprising O, S, SO, SO, Se and CH, and with the proviso that at least one of the Xis not CH, and or a salt, prodrug or complex thereof is used in the treatment and/or prevention of primary and secondary metastatic neoplasms.

Fatty acid analogues for the treatment of cancer

The present invention relates to fatty acid analogues of the general formula (I): R-[x-CH]&#x2014;COORwherein Ris; a C&#x2013;Calkene with one or more double bonds and/or with one or more triple bonds, and/or a C&#x2013;Calkyne, and/or a C&#x2013;Calkyl, or a C&#x2013;Calkyl substituted in one or several positions with one or more compounds selected from the group comprising fluoride, chloride, hydroxy, C&#x2013;Calkoxy, C&#x2013;Calkylthio, C&#x2013;Cacyloxy or C&#x2013;Calkyl, and wherein R2 represents hydrogen or C&#x2013;Calkyl, and wherein n is an integer from 1 to 12, and wherein i is an odd number and indicates the position relative to COOR, and wherein Xindependent of each other are selected from the group comprising O, S, SO, SO, Se and CH, and with the proviso that at least one of the Xis not CH, and with the proviso that if R1 is an alkyne or alkene, then the carbon-carbon triple bond or double bond is positioned between the (&#x3c9;-1) carbon and the (&#x3c9;-2) carbon, or between the (&#x3c9;-2) carbon and the (&#x3c9;-3) carbon, or between the (&#x3c9;-3) carbon and the (&#x3c9;-4) carbon, which can be used for the treatment and/or prevention of proliferative skin disorders. More specifically the invention relates to the inhibition of proliferation and/or differentiation of keratinocytes.

Fatty acid analogues for the treatment of proliferative skin disorders

The present invention relates to novel fatty acid analogues of the general formula (I): CH&#x2014;[CH]&#x2014;[x&#x2014;CH]&#x2014;COOR, wherein n is an integer from 1 to 12, and wherein m is an integer from 0 to 23, and wherein i is an odd number which indicates the position relative to COOR, and wherein Xindependent of each other are selected from the group comprising O, S, SO, SO, Se and CH, and wherein R represents hydrogen or C&#x2013;Calkyl, with the proviso that at least one of the Xis not CH, or a salt, prodrug or complex thereof, for the preparation of a pharmaceutical composition for the treatment and/or prevention of primary and/or secondary stenosis. Further the present invention relates to the use of said compounds for the prevention and/or treatment of a disease caused by procedural vascular trauma and/or pathological proliferation of smooth muscle cells, and/or an increased level of plasma homocysteine.

Fatty acid analogues for the treatment of diseases caused by the pathological proliferation of smooth muscle cells

The present invention relates to novel fatty acid analogous of the general forumla I: CH &mdash;&lsqb;CH &rsqb; &mdash;&lsqb;x &mdash;CH &rsqb; &mdash;COOR, as defined in the specification, which can be used for the treatment and/or prevention of obesity, fatty liver and hypertension. Further, the invention relates to a nutritional composition comprising such fatty acid analogues, and a method for reducing the total weight, or the amount of adipose tissue in an animal. The invention also relates to a method for improving the quality of product such as meat, milk and eggs.

Fatty analogues for the treatment of obesity, hypertension and fatty liver

The present invention relates to novel fatty acid analogues of the general formula (I): CH &mdash;&lsqb;CH &rsqb; &mdash;&lsqb;X &mdash;CH &rsqb; &mdash;COOR, wherein n is an integer from 1 to 12, and wherein m is an integer from 0 to 23, and wherein i is an odd number which indicates the position relative to COOR, and wherein X independent of each other are selected from the group comprising O, S, SO, SO , Se and CH , and wherein R represents hydrogen or C -C alkyl, with the proviso that at least one of the X is not CH , or a salt, prodrug or complex thereof, for the preparation of a pharmaceutical composition for the treatment and/or prevention of primary and/or secondary stenosis. Further the present invention relates to the use of said compounds for the prevention and/or treatment of a disease caused by procedural vascular trauma and/or pathological proliferation of smooth muscle cells, and/or an increased level of plasma homocysteine.

Fatty acid analogues for the treatment of primary and secondary restenosis

The present invention relates to novel fatty acid analogues of the general formula (I): CH &mdash;&lsqb;CH &rsqb; &mdash;&lsqb;x &mdash;CH &rsqb; &mdash;COOR, as defined in the specification, which can be used for the treatment and/or prevention of diabetes. Further, the invention relates to a nutritional composition comprising such fatty acid analogues.

Growing community of inventors

Bønes, Norway

Rolf Kristian Berge