Roche Molecular Systems, Inc.

Hoffmann-la Roche Inc.

Roche Diagnostics Operations, Inc.

Roche Diagnostics Gmbh

F. Hoffmann-la Roche Ag

Rolf Knobel

Andreas Gisler

Robert Huesler

Paul Frank

Christian Thalmann

Renato Belz

Markus Rinderknecht

Siegfried Mueller

Heinz Trueeb

Urs Schnieper

Ronald T Kurnik

Laurent Francioli

Rik Harbers

Jean-Pierre Bolliger

Herbert Burch

Kurt Barmettler

Carsten Haack

Joerg Burmester

Jörg Burmester

A method of determining a level of interference with a photometric in-vitro diagnostic assay and an in-vitro diagnostic analyzer for carrying out the method are described. An aliquot of a sample is treated with at least one reagent to obtain a sample/reagent mixture and subjecting the sample/reagent mixture to a photometric measurement in order to obtain a result of the in-vitro diagnostic assay, and during the same photometric measurement determining a preliminary level of interference by semi-quantitatively determining one or more interfering substances in the same sample/reaction mixture. A separate photometric measurement of another aliquot of the same sample either undiluted or diluted with a liquid other than a reagent is triggered in order to determine an effective level of interference by quantitatively determining the one or more interfering substances, only upon determining a preliminary level of interference above a predetermined threshold.

Photometric interference determination

An automated method for determining a coagulation result of a biological sample is presented. The method includes obtaining a time series representing measurement data of a sample. The time series spans a period in which a clotting reaction is supposed to take place. The method includes obtaining a global model function configured to model measurement data of a sample in which a clotting reaction takes place. The global model function is configured to model the measurement data as a sigmoidal shape with at least one inflection point. The absolute value of the maximum curvature of the sigmoidal shape is larger on one side of the at least one inflection point than on the other side. The method includes fitting the model function to the time series representing measurement data to obtain a fitted model function and determining a coagulation result of the sample based on the fitted model function.

Techniques for determining coagulation results

A method for determining a background shift is presented. The method includes obtaining a plurality of optical measurement sets of a sample taken by a sample analyzer at different points in time. Each set includes one measurement taken in a first channel and another measurement taken in a second channel different from the first channel. The plurality of optical measurement sets includes one set group and another set group. The measurements in the one set group show a higher signal change than the measurements in the other group. A first background signal is determined based on a relation of measurements in the first and second channels in the one group. A second background signal is determined based on a relation of measurements in the first and second channels in the one group and the other group. A background shift is determined based on the first and second background signals.

Signal offset determination and correction

The present invention relates to an automated analytical system and an automated method for separating and detecting an analyte, as well as an automated analytical instrument.

System for separating and detecting an analyte

An automated analyzer with an on-board fridge for long-term cooling of reagents, and a method for isolating and analyzing an analyte comprising long-term cooling of reagents.

Reagent store

The invention relates to a method of isolating and analyzing an analyte using an analytical apparatus which comprises modules of different types, wherein any one module of one type has a specific, pre-defined timing for carrying out its workflow.

Workflow timing between modules

A method is described for distributing samples within an automated analyzer from a linear arrangement of sample vessels to a processing plate in a two-dimensional n&#xd7;m arrangement wherein samples are sorted, followed by transfer with a pipetting device with a linear arrangement to a processing vessel in a two-dimensional n&#xd7;m arrangement and subsequent processing of samples using a second pipetting device which has a two-dimensional n&#xd7;m arrangement.

Sample distribution in a method for isolating analytes in fluid samples in an automated system

Sample distribution in an analytical system for processing an analyte

A method for separating and analyzing an analyte is provided which comprises, in a first position, transferring a liquid sample to a multiwell plate with a pipette tip, replacing the tips in the tip rack in the same position, and re-using the pipette tips for aspirating and dispensing liquid.

Method for separating and detecting an analyte

Automated method for sample distribution and isolation of an analyte with a solid support

Subjects of the invention are a method for determination of an analyte using a particular algorithm based on a mathematical model for transforming measurement data into a growth curve and an analytical instrument comprising a computing unit for more precise determination of an analyte.

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Rotkreuz, Switzerland

Rolf Knobel