Sanofi-a Ventis Deutschland Gmbh

Rolf Hoerlein

Wolfgang Holla

Frank Zocher

Stephane Mutti

Bernd Junker

Berndt Kulitzscher

Thomas Stuedemann

Jochen Hachtel

Christophe Salagnad

Christoph Tappertzhofen

Claus-Jügen Maier

The invention relates generally to a process for preparing diarylcycloalkyl derivatives of the formula (I). wherein the respective R-group substituents are defined herein. These compounds of formula (I) are activators for peroxisome proliferator-activated receptors (PPAR activators) which are useful in the therapeutic treatment of a number of diseases and disorders of the central nervous system such as multiple sclerosis, Parkinson's Disease, psychiatric disorders and the like. The present invention is a novel process for preparing PPAR activators of the formula (I) which do not have the disadvantages of the processes known in the prior art. In particular, a process is provided with which the PPAR activators of formula (I) can be prepared in a suitable enantiomeric excess, i.e. high enantioselectivity, without the need for subsequent chiral chromatography.

Method for the production of diarylcycloalkyl derivatives

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Frankfurt-am-Main, Germany

Rolf Hoerlein