Consortium Fur Elektrochemische Industrie Gmbh

Rolf Hirsenkorn

Wolfgang Haas

Helmut Reuscher

Silke Scheiding

Silvia Orlitsch

Petra Grauvogl

Reactive cyclodextrin derivatives have at least one nitrogen-containing heterocycle. The reactive cyclodextrin derivatives include at least one nitrogen-containing heterocycle having at least one electrophilic center.

Cyclodextrin derivatives having at least one nitrogen-containing

Acylated cyclodextrins of the formula I: ##STR1## where R denotes hydrogen or R1, and R1 is identical or different and denotes acetyl, propionyl, butyryl, 2-alkoxyacetyl, 2-chloroacetyl, 2-fluoroacetyl, 2-N-acetylaminoacetyl, methacryloyl or acryloyl, and the DS for R1, measured by means of .sup.1 H NMR spectroscopy, is between 0.3 and 2.0.

Acylated .gamma.-cyclodextrins

Partially acylated cyclodextrins of the formula I ##STR1## where R denotes hydrogen or R1, wherein R1 can be identical or different and denotes acetyl, propionyl, butyryl, 2-alkoxyacetyl, 2-chloroacetyl, 2-fluoroacetyl, 2-N-acetylaminoacetyl, methacryloyl or acryloyl, and the DS for R1, measured by means of .sup.1 H NMR spectroscopy, is between 0.30 and 1.20; and a process for preparing partially acylated .beta.-cyclodextrins and also a process for their use.

Partially acylated .beta.-cyclodextrins

A process for preparing amino-functional cyclodextrin derivatives has an amino function which is linked to the cyclodextrin (CD) via a spacer. Compositions containing CD derivatives are prepared by this process. In this process, .alpha.-cyclodextrin, .beta.-cyclodextrin or .gamma.-cyclodextrin, or their partially substituted derivatives, is reacted individually or in arbitrary mixture with at least one cyclic carbamic ester. The CD derivatives, as regards the listed amino substituents, have an average degree of molar substitution per anhydroglucose unit (MS) of 0.01-0.2 and a proportion of monoamino-substituted CD derivatives which is greater than 70%.

Process for preparing amino-functional cyclodextrin derivative

A process for preparing branched cyclodextrins has at least one cyclodextrin or cyclodextrin derivative reacted with at least one glycosyl donor in a molar ratio of cyclodextrin/glycosyl donor of from 1:1 to 1:20, in the presence of a catalyst, and in a solvent.

Process for preparing branched cyclodextrins

The invention relates to a process for the preparation of 1-alkyl-1,2,3,4-tetrahydroisoquinoline derivatives of the general formula ##STR1## The compounds can be used for the preparation of tetrahydroisoquinolines of the reticuline type, or of the norreticuline type, by reductive removal of the OH groups or, if they carry an acyl protective group on the nitrogen, for the preparation of isoquinolines of the papaverine type by acid-catalyzed hydrolysis with removal of the acyl groups and simultaneous removal of the hydroxyl groups. These 1-alkyl-1,2-dihydroisoquinoline derivatives can then be used for the preparation of isoquinolines of the papaverine type by aromatization by means of acids or hydrazine.

Process for the preparation of 1-alkylisoquinoline derivatives

Process for the preparation of .beta.-resorcylic acid derivatives of the general formula ##STR1## in which R, R.sup.2 and R.sup.3 can be identical or different and denote a hydrogen atom or an alkyl radical and R.sup.1 and R.sup.4 can be identical or different and denote an alkyl radical, by reaction of a diketone with .beta.-ketocarboxylic acid derivatives in the presence of an alkaline earth metal compound. The derivatives are useful as fragrances, or in perfumes.

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Munchen, Germany

Rolf Hirsenkorn