Ciba Specialty Chemicals Corporation

Intrexon Corporation

Wista Laboratories Ltd.

The State University of New York

Bayer Corporation

Mutual Pharmaceutical Company, Inc.

Takeda Pharmaceuticals U.s.a., Inc.

Rolf Hilfiker

Robert Eugene Hormann

Inna Shulman

Susan Margaret De Paul

Eva Rödel

Gerhard Reinert

Francesco Fuso

Werner Kaufmann

Tong Sun

Timo Rager

Shawn Watson

Andreas Sieber

Kurt Nielsen

Dieter Reinehr

Benjamin Chu

Marcus Baumann

Say-Jong Law

Anand Natrajan

Qingping Jiang

David J Sharpe

Adrian Waldner

Alex Alder

Hanspeter Gysin

Urs Hofer

Hans Peter Harri

Jun Xi

Erika Schmidt

Paul Senn

Fritz Thommen

Robert Truniger

The present disclosure provides crystalline polymorphic and amorphous forms of (R)-3,5-dimethyl-benzoic acid N-(1-tert-butyl-butyl)-N'-(2-ethyl-3-methoxy-benzoyl)-hydrazide (Compound 1) or (S)-3,5-dimethyl-benzoic acid N-(1-tert-butyl-butyl)-N&#x2032;-(2-ethyl-3-methoxy-benzoyl)-hydrazide (Compound 2). The present disclosure further provides compositions comprising crystalline polymorphic and amorphous forms of Compound 1 or Compound 2 and an excipient, methods of making crystalline polymorphic or amorphous forms of Compound 1 or Compound 2, and methods of using crystalline polymorphic or amorphous forms of Compound 1 or Compound 2 to regulate gene expression in a cell or in a subject.

Crystalline diacylhydrazine and the use thereof

Disclosed are new colchicine solid-state forms, methods of preparing the solid-state forms, as well as formulations prepared therefrom and uses thereof.

Colchicine solid-state forms; methods of making; and methods of use thereof

Substantially pure methylthioninium chloride pentahydrate form A is prepared from methylthioninium chloride by phase equilibration of suspensions, crystallization or solvent evaporation, whereby the water content of the solvent corresponds to a water activity of at least 0.4 at 25&#xb0; C., and controlled drying of said methylthioninium chloride pentahydrate form A within its stability ranges of humidity, pressure and temperature.

Process for the preparation of substantially pure methylthionium chloride pentahydrate form A

Three dihydrate forms B, C and D and a monohydrate form E of methylthioninium chloride are described. Forms B, C, D and E can be prepared under controlled humidity and temperature from methylthioninium chloride with higher water content or conversion of a hydrate. The hydrates can be incorporated in pharmaceutical compositions.

Crystalline methylthioninium chloride hydrates

A new class of chemiluminescent acridinium or benzacridinium compounds is disclosed by virtue of forming an intramolecular energy transfer conjugate (ETC) between the acridinium or benzacridinium compound and a luminophore. A method of extending the emission wavelengths of acridinium or benzacridinium esters in order to further reduce or eliminate the emission spectral overlap between the parent polysubstituted aryl Acridinium Esters (DMAE) and Benzacridinium Esters (LEAE) is disclosed. The ETC's retain the unique desired properties of acridinium or benzacridinium compounds including complete light emission in very short period of time, monophasic emission spectrum, simplicity of triggering mechanism, ability of labeling the biological molecules of interest to form a tracer, and good stability. Additionally, the range of the emission spectrum of an acridinium or benzacridinium compound can now be shifted at will and at longer leap through the choice of a luminophore as the integral part of an ETC molecule. Disclosed are chemiluminescent labeled conjugates comprising an acridinium or benzacridinium moiety covalently attached to a luminophore via a spacer, said moiety further conjugated to a biological molecule of interest, wherein said spacer is of an appropriate length to allow the excited species generated from said moiety to transfer energy efficiently to said luminophore, resulting in the emission of light in the spectral region of said luminophore. Also disclosed are binding assays using said conjugates, test kits comprising said conjugates and methods of preparing the conjugates.

Chemiluminescent energy transfer conjugates and their uses as labels in

Process for increasing the sun protection factor of cellulosic fibre

Process for increasing the sun protection factor of cellulosic fiber

The present invention provides an aqueous textile treatment composition comprising:

Aqueous textile treatment compositions containing an ultra-violet

The present invention relates to a improving the sun protection factor (SPF) of textile fibre material comprising treating the textile fibre material with a composition comprising at least one flourescent whitening agent which absorbs radiation in the wavelength range 280-400 nm.

Textile treatment

A magnetic sphere or needle rheometer which may be fully controlled by a personal computer is provided. The rheometer is capable of measuring viscosities in the range of 5.times.10.sup.-4 to 5.times.10.sup.4 Pas (0.5 cP to 5.times.10.sup.7 cP). It can operate at shear rates between 1 s.sup.-1 and 2.times.10.sup.-4 s.sup.-1 and measure relaxation times down to 100 ms. The rheometer includes a magnetic coil which is used to maintain the sphere or needle in a selected position within a sample cell. The current required to maintain the sphere or needle in this position as the sample cell is moved up or down is measured. The viscosity of the liquid can be calculated from the difference in current flowing through the coil when the cell is stationary and when it is moved at a constant velocity.

Rheometer

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Allschwil, Switzerland

Rolf Hilfiker