Ludwig Heumann & Co. Gmbh

Heumann Pharma Gmbh & Co.

Rolf Herter

Helmut Schickaneder

Kurt H Ahrens

Peter Morsdorf

Istvan Szelenyi

Stefan Postius

Heidrun Engler

Volker Pfahlert

Kurt-Henning Ahrens

Reinhold Weidner

Walter Schunack

Herbert Hansen

Hartmut Vergin

Kurt Wegner

Volker Pfanhlert

Geidrun Engler

New diazine derivatives corresponding to the general formula I ##STR1## and the physiologically acceptable salts thereof are described. The compounds according to the invention are new positive inotropic compounds having a higher and/or more selective action than compounds hitherto known and are therefore suitable for the treatment and prevention of diseases of the heart and circulation.

Cardiotonic thiadiazine derivatives

New benzimidazoles correponding to the general formula I ##STR1## are described, in which the pyridazinone ring is attached in the 5- or 6- position of the benzimidazole ring and R.sup.1 denotes a hydrogen atom or a straight chained or branched C.sub.1 to C.sub.4 alkyl group, R.sup.2 denotes a hydrogen atom, a straight chained or branched C.sub.1 to C.sub.4 alkyl group, a C.sub.1 to C.sub.4 alkoxy group, a hydroxy group, a halogen atom, an amino group or a nitro group, A denotes a hydrogen atom, a group of the formula ##STR2## wherein R.sup.3 denotes a hydrogen atom, an optionally substituted C.sub.1 to C.sub.4 alkyl group or a C.sub.1 to C.sub.4 alkoxy group and B denotes a cyano group, a benzoyl group or a phenylsulphonyl group, or A denotes a group of the formula ##STR3## in which m has the value 2 or 3 and n represents an integer from 1 to 6, and the physiologically acceptable salts thereof as well as processes for their preparation and pharmaceutical preparations. containing these compounds These compounds are new, effective, positive inotropic substances which do not act by the mechanism of phosphodiesterase inhibition.

Benzimidazoles and pharmaceutical preparations containing these compounds

New 6-oxo-pyridazine derivatives corresponding to the general formula I ##STR1## which represent new, positive inotropic compounds having a higher and more selective inotropy-increasing activity are described. A process of preparation and the medical use of these substances or of a medicament containing these substances are also described.

6-oxo-pyridazine derivatives, a process for their preparation and

New benzimidazoles corresponding to the general formula I ##STR1## are described, in which the pyridazinone ring is attached in the 5- or 6- position of the benzimidazole ring and R.sup.1 denotes a hydrogen atom or a straight chained or branched C.sub.1 to C.sub.4 alkyl group, R.sup.2 denotes a hydrogen atom, a straight chained or branched C.sub.1 to C.sub.4 alkyl group, a C.sub.1 to C.sub.4 alkoxy group, a hydroxy group, a halogen atom, an amino group or a nitro group, A denotes a hydrogen atom, a group of the formula ##STR2## wherein R.sup.3 denotes a hydrogen atom, an optionally substituted C.sub.1 to C.sub.4 alkyl group or a C.sub.1 to C.sub.4 alkoxy group and B denotes a cyano group, a benzoyl group or a phenylsulphonyl group, or A denotes a group of the formula ##STR3## in which m has the value of 2 or 3 and n represents an integer from 1 to 6, and the physiologically acceptable salts thereof as well as processes for their preparation and pharmaceutical preparations containing these compounds. These compounds are new, effective, positive inotropic substances which do not act by the mechanism of phosphodiesterase inhibition.

Benzimidazoles, and pharmaceutical preparations containing these

New 6-phenyldihydro-3(2H)-pyridazinones corresponding to the following general formula ##STR1## are described. These compounds are readily prepared in a form suitable for oral administration and are distinguished by a high positive inotropic action and have only a slight effect on blood pressure and cardiac frequency. A process for their preparation and pharmaceutical preparations containing these compounds are also described.

Piperazine substituted 6-phenyldihydro-3(2H)-pyridazinones, and

The invention relates to new 1,4-piperazine compounds corresponding to the following general formula ##STR1## which show improved antimycotic activity in relation to the known compounds miconazol and ketoconazol.

4-[4-[[2-(halophenyl)-2-[1H-tr:azol(or

1,3,4-Thiadiazole derivatives corresponding to the general formula I ##STR1## which constitute highly effective inhibitors for histamine-H.sub.2 receptors are described. These compounds in addition have a cytoprotective action.

1,3,4-Thiadiazole derivatives and pharmaceutical preparations useful as

Special pyrazole derivatives corresponding to the general formula I which have a highly selective action on histamine-H.sub.2 receptors are described. Compared with other drugs known to be effective in their action on histamine-H.sub.2 receptors, these compounds have improved pharmacological properties. A method of preparation of these compounds is also described.

Pyrazole derivatives, processes for their preparation and pharmaceutical

Alkanol derivatives corresponding to the general formula I

Alkanol derivatives, and pharmaceutical preparation containing these

Diamine derivatives corresponding to the general formula I

Diamine derivatives and pharmaceutical preparations containing these

The invention relates to new propan-2-ol derivatives corresponding to the following general formula ##STR1## in which R represents ##STR2## and to salts thereof with pharmacologically acceptable acids. These compounds have a selective effect on histamine-H.sub.2 -receptors.

Propan-2-ol derivatives, a process for their production and medicaments

The invention relates to new pyridine-pyrimidinone derivatives corresponding to the following general formula ##STR1## wherein R.sup.1 represents linear C.sub.1-6 alkyl or cycloalkyl and R.sup.2 represents linear C.sub.1-6 alkyl or R.sup.1 and R.sup.2 together with the nitrogen atom form a pyrrolidine or piperidine ring;

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Schwabach, Germany

Rolf Herter