Eth Zurich

Unversität Zürich

Universitaet Zuerich

Otto-von-guericke-universität Magdeburg

Rolf Graf

Philipp Rudolf Von Rohr

Pierre-Alain Clavien

Marius Keel

Dilmurodjon Eshmuminov

Daniel Bimmler

Martin Schuler

Dustin Becker

Philipp Dutkowski

Xavier Muller

Lucia Bautista Borrego

Max Leo Hefti

Martin Jörg Schuler

Brian Burg

Hans-Ulrich Schulz

Walter Halangk

Raphael Gukasjan

A perfusion loop assembly for ex vivo liver perfusion includes a pump providing perfusion fluid through a line branching at a branching point into a first branch line and a second branch line. The first branch line provides a first portion of the perfusion fluid to the hepatic artery of the liver, the first branch line coupled with a gas exchanger, where the first branch line includes a flow rate sensor and/or a pressure sensor. The second branch line provides a second portion of the perfusion fluid to the portal vein of the liver; the second branch line includes a valve for controlling flow of perfusion fluid into the portal vein. The second branch line includes a flow rate sensor and/or a pressure sensor. A liver chamber assembly holds the liver ex vivo, and an outlet line for the perfusion fluid connects the liver chamber assembly and the pump.

Perfusion loop assembly for an ex-vivo liver perfusion and a method for ex-vivo liver perfusion

The present invention relates to a perfusion loop assembly for an ex vivo liver perfusion including: a pump for providing a fluid flow of a perfusion fluid through a first branch line and a second branch line; the first branch line being configured to provide a first portion of the perfusion fluid to the hepatic artery of the liver; the first branch line being coupled with a first gas exchanger, the second branch line being configured to provide a second portion of the perfusion fluid to the portal vein of the liver; the second branch line further including a first valve for controlling the flow of the perfusion fluid into the portal vein of the liver, a liver chamber assembly configured to hold the liver ex vivo, a liver outlet line attached to the vena cava of the ex vivo liver, at least one reservoir connected to the liver outlet and upstream from the pump.

Perfusion loop assembly for an ex-vivo liver perfusion and a liver chamber assembly

The present invention relates to a reliable method of prediction of sepsis in humans after a trauma, wherein the level of pancreatic stone protein/regenerating protein (PSP/reg) is determined in serum, and a high level is indicative of the development of sepsis at early stages of the disease. Furthermore a method of determination of PSP/reg levels in serum is described.

Method for assaying sepsis in humans

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Zurich, Switzerland

Rolf Graf