Hoechst Aktiengesellschaft

Rolf Graeve

Dirk Seiffge

Ismahan Okyayuz-Baklouti

Werner Thorwart

Klaus U Weithmann

Ruth Raiss

Stefan M Ullner

Phosphonoacetic acid derivatives and their use for treating degenerative joint disorders Compounds of the formula I ##STR1## are suitable for producing pharmaceuticals for the treatment and prophylaxis of degenerative joint disorders, of rheumatic disorders accompanied by cartilage breakdown, such as rheumatoid arthritis, joint trauma and chondrolysis as a consequence of prolonged immobilization of the joint, of inflammations, septic shock, disorders with impaired leukocyte adhesion, disorders caused by an elevated concentration of tumor necrosis factor alpha, such as cachexia or Crohn's disease.

Phosphonoacetic acid derivatives and their use for treating degenerative

Imidazole compounds of the formula I ##STR1## in which R.sup.1 =alkyl,

Imidazole compounds, processes for their preparation, pharmaceuticals

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Taunusstein, Germany

Rolf Graeve