The United States of America as Represented by the Department of Health

The United States of America, as Represented by the Secretary, Department of Health and Human Services

Rolf G Tschudin

James B Mitchell

Sankaran Subramanian

Murali K Cherukuri

Ramachandran Murugesan

Paul D Smith

Thomas J Pohida

Walter S Friauf

Mark S Mirotznik

Murali Krishna Cherukuri

Bradley Allen Roth

Frank S Harrington

Angelo Russo

Nallathamby Devasahayam

John Bourg

John A Cook

Paul G Zablocky

Mobae Afeworki

A radiofrequency (RF) coil design, suitable for detecting time domain electron paramagnetic resonance (EPR) responses from spin probes after pulsed excitation using radiofrequency irradiation (60-400 MHz), is configured in an array of numerous surface coils of appropriate diameters connected in a parallel or axial configuration with appropriate spacing between individual surface coils to form a volume type resonator.

Resonant structure for spatial and spectral-spatial imaging of free radical spin probes using radiofrequency time domain electron paramagnetic resonance spectroscopy

A system for performing pulsed RF FT EPR spectroscopy and imaging includes an ultra-fast excitation subsystem and an ultra-fast data acquisition subsystem. Additionally, method for measuring and imaging in vivo oxygen and free radicals or for performing RF FT EPR spectroscopy utilizes short RF excitations pulses and ultra-fast sampling, digitizing, and summing steps.

In vivo imaging and oxymetry by pulsed radiofrequency paramagnetic

A gated RF preamplifier used in system for performing pulsed RF FT EPR spectroscopy and imaging or MRI. The RF preamplifier does not overload during a transmit cycle so that recovery is very fast to provide for ultra-fast data acquisition in an ultra-fast excitation subsystem. The preamplifier includes multiple low-gain amplification stages with high-speed RF gates inserted between stages that are switched off to prevent each stage from overloading during the transmit cycle.

Gated RF preamplifier for use in pulsed radiofrequency electron

System and method for performing in vivo imaging and oxymetry and FT

An EPR imager and spectrometer includes pulse generating system for generating broadband pulses having an RF carrier frequency that is not highly absorbed by biological samples. The pulse generating system includes up and down chirp convertors for frequency modulating a carrier frequency pulse and compressing the frequency modulated pulse to form a broadband excitation pulse of high energy. Such a machine could form the basis of a clinical imaging device capable of high sensitivity to free radical species in human patients.

Pulsed low frequency EPR spectrometer and imager

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Kensington, MD, United States of America

Rolf G Tschudin