Boehringer Ingelheim International Gmbh

Boehringer Ingelheim Pharma Gmbh & Co Kg

Boehringer Ingelheim Kg

Boehringer Ingelheim Pharma Kg

Rolf Dach

Helmut Heitger

Norbert Hauel

Oliver Meyer

Ingo Heddesheimer

Hermann Mueller-Boetticher

Stefan Schmitt

Frieder Gnad

Jingshan Shen

Yi Jing Zhu

Xiangrui Jiang

Joerg Brandenburg

Hanfried Baltes

Werner Belzer

Jin Suo

Siegfried Meineck

Hartmut Schmidt

Wilfried Goldschmidt

Juan M Rodriguez Dehli

Markus Heitzmann

Volker Fachinger

Juan M Rodriguez-Dehli

Seigfried Meineck

Yi Zhu

A process for preparing telmisartan by reacting 2-n-propyl-4-methyl-6-(1'-methylbenzimidazol-2&#x2032;-yl)benzimidazole with a compound of formula (IV) wherein Z is a leaving group, to obtain the compound 2-cyano-4&#x2032;-[2&#x2033;-n-propyl-4&#x2033;-methyl-6&#x2033;-(1&#x2032;&#x2033;-methylbenzimidazol-2&#x2032;&#x2033;-yl)benzimidazol-1&#x2033;-ylmethyl]biphenyl, and subsequently hydrolyzing the nitrile function to obtain the acid function.

Process for manufacture of telmisartan

An improved process for preparing dabigatran etexilate, as well as analogous compounds of formula 7, is described.

Process for the manufacture of dabigatran etexilate

Subject of the present invention is a new improved process for the preparation of nitroorotic acid via nitration of orotic acid.

Process for the preparation of nitroorotic acid

The invention relates to a method for producing 1,3-dioxolane-2-ones of general formula (3) in basic reaction conditions by reesterifying the respective ester of general formula (1) in which R1 to R5 have the meanings indicated in the claims and the description. The invention further relates to a method for producing 2-hydroxy carboxylic acid esters of general formula (5) with or without isolation of the intermediate in the form of a derivative of the 1,3-dioxolane-2-one of general formula (3) in basic reaction conditions by reesterifying the respective ester of general formula (1) in which R1, R2, and R6 have the meanings indicated in the claims and the description. The method according to the invention allows the reaction to take place in very gentle basic conditions, causing fewer secondary reactions and providing a greater yield than reactions in highly polar aprotic solvents. Acid-sensitive and/or temperature-sensitive compounds can be synthesized. 

Method for the production of 1,3-dioxolane-2-ones and carboxylic acid esters by means of transacylation in basic reaction conditions

A process for preparing 1,7'-dimethyl-2&#x2032;-propyl-2,5&#x2032;-bi-1H-benzimidazole of formula (I) reacting N-methyl-o-phenylenediamine of formula (II) or the salts thereof with 2-propyl-4-methyl-1H-benzimidazole-6-carboxylic acid of formula (III) or the salts thereof wherein the coupling and cyclization is achieved using 1,3,5-triazine and tertiary amine.

[object Object]

Disclosed is a process which can be used on an industrial scale for preparing and purifying 1,7&prime;-dimethyl-2&prime;-propyl-2,5&prime;-bi-1H-benzimidazole in which the crude product is subjected to charcoal treatment.

Process for preparing and purifying 1,7&prime;-dimethyl-2&prime;-propyl-2,5&prime;-bi-1H-benzimidazole

Process for the production of epinastine hydrochloride in the high-melting crystal modification

The present invention relates to an improved process for preparing 1,3-dimethyl-4,5-diaminouracil by catalytic reduction of 1,3-dimethyl-4-amino-5-nitrosouracil in the presence of a palladium/charcoal catalyst.

Process for preparing 1,3-dimethy-4,5-diaminouracil

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Gau-Algesheim, Germany

Rolf Dach