Other

Pharmacia Ab

Pharmacia & Upjohn Ab

Pfizer Health Ab

Kabivitrum Ab

Rolf A Johansson

Lisbeth Nilvebrant

Erik Ringberg

Katarina Beierlein

Martin Haraldsson

Birger Sjoberg

Pinchas Moses

Eva ANGkerblom

Birgitta Weinz

Bengt A Sparf

Carl Magnus Svahn

Karin H Bergendal

Bengt Ang Sparf

Ian Vagberg

Bengt ANGke Sparf

The invention relates to 3,3-diphenylpropylamines of formula (I), wherein Rsignifies hydrogen or methyl, Rand Rindependently signify hydrogen, methyl, methoxy, hydroxy, carbamoyl, sulphamoyl or halogen, and X represents a tertiary amino group of formula (II), wherein Rand Rsignify non-aromatic hydrocarbyl groups, which may be the same or different and which together contain at least three carbon atoms, and wherein Rand Rmay form a ring together with the amine nitrogen, their salts with physiologically acceptable acids and, when the compounds can be in the form of optical isomers, the racemic mixture and the individual enantiomers. The invention also relates to methods for their preparation, pharmaceutical compositions containing the novel compounds, and the use of the compounds for preparing drugs

3,3-diphenylpropylamines, their use and preparation

3,3-Diphenylpropylamines, their use and preparation

The invention relates to novel compounds of Formula (I) wherein R,, R,, R,, R,, R,, R,, R,and Ar are as defined in claim,their salts with physiologically acceptable acids and, when the compounds can be in the form of optical isomers, the racemic mixture and the individual enantiomers. The compounds have anticholinergic activity, and the invention also relates to the compounds of Formula (I), the use of the compounds of Formula (I) for preparing anticholinergic drugs, the use of the compounds of Formula (I) for treating urinary tract incontinence, and methods for preparing the compounds of Formula (I).

Therapeutically active diarylpropylamines; their pharmaceutically acceptable salts; a method for their preparation and method for their use

Arylcycloalkane carboxylic esters, their use, pharmaceutical

A 3,3-diphenylpropylamine of the formula I, or its physiologically acceptable acid salt thereof: ##STR1## wherein R.sup.1 represents hydrogen or methyl, R.sup.2 and R.sup.3 independently represent hydrogen, methyl, methoxy, hydroxy, carbamoyl, sulphamoyl or halogen, and X represents a tertiary amino group of formula II ##STR2## wherein R.sup.4 and R.sup.5 independently represent a hydroxy substituted or unsubstituted non-aromatic hydrocarbyl group which can join together to form a ring and which together contain at least three carbon atoms, wherein at least one of R.sup.4 and R.sup.5 is hydroxy substituted, is useful in treating acetylcholine-mediated disorders such as urinary incontinence.

The invention relates to 3,3-diphenylpropylamines of formula (I), wherein R.sup.1 signifies hydrogen or methyl, R.sup.2 and R.sup.3 independently signify hydrogen, methyl, methoxy, hydroxy, carbamoyl, sulphamoyl or halogen, and X represents a tertiary amino group of formula (II), wherein R.sup.4 and R.sup.5 signify non-aromatic hydrocarbyl groups, which may be the same or different and which together contain at least three carbon atoms, and wherein R.sup.4 and R.sup.5 may form a ring together with the amine nitrogen, their salts with physiologically acceptable acids and, when the compounds can be in the form of optical isomers, the racemic mixture and the individual enantiomers. The invention also relates to methods for their preparation, pharmaceutical compositions containing the novel compounds, and the use of the compounds for preparing drugs ##STR1##

Novel heparin derivatives

A belt conveyor with dual upper runs and dual lower runs defined by a single continuous belt for synchronized movement of the upper runs. The dual lower runs cross each other and are guided by longitudinally spaced support rollers which twist the lower belt runs and vertically shift at least one of these lower runs to provide for free unencumbered crossing of the lower belt runs and the keepers mounted on the belt to assist in movement of material.

Belt conveyor system

Multiple belt conveyar with synchronizer

Growing community of inventors

Huddinge, Sweden

Rolf A Johansson