Farmila-Thea Farmaceutici S.p.a.

Farmila-Thea Faraceutici S.p.a.

Rolando Barbucci

Giancarlo Sportoletti

Roberto Rappuoli

Cross-linked hyaluronic acids produced by the reaction of the carboxylic acid groups of hyaluronic acid and a polyamine and the sulfated and hemisuccinylated derivates thereof. The cross-linked hyaluronic acids are useful for various pharmaceutical and medical purposes.

Cross-linked hyaluronic acids and medical uses thereof

A process for the preparation of cross-linked polysaccharides containg carboxy groups. The process comprises a first step of activating the carboxy groups in an anhydrous aprotic solvent and then reacting with a polyamine. The cross-linked polysaccharide may be subjected to sulfonation of the five hydroxy groups.

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Milan, Italy

Rolando Barbucci