Vilnius University

Bayer Intellectual Property Gmbh

Bayer Technology Services Gmbh

Uab Biomatter Designs

Rolandas Meskys

Rainhard Koch

Walter Weichel

Ruth Meissner

Volker Möhrle

Daiva Tauraite

Markus Schindler

Irmantas Rokaitis

Rita Meskiene

Rasa Semenaite

Vida Casaite

Jevgenija Jakubovska

Vykintas Jauniskis

Liucija Marcinkeviciene

Laurynas Karpus

Irina Bachmatova

Ignas Mazelis

The present invention relates to catalytic biomolecule characterization and microfluidics. It is used for identification of nucleic acids encoding active catalytic molecules in the plurality of nucleic acids and for gathering information about catalytic biomolecule activity. It can also be used for exploring different properties of regulating sequences that modulate expression of catalytic biomolecules by recording that information into the DNA sequence of the same catalytic biomolecule using microfluidic techniques.

Catalytic biomolecule activity recording into DNA sequence

Disclosed are W-position modified cytidine nucleotides of formula (I). Provided herein are methods of chemical synthesis of AP-modified cytidine nucleoside triphosphates and their applications as well as uses of the cytidine analogues for the synthesis of modified nucleic acids. The nucleic acid molecule includes DNA, RNA or a combination of DNA/RNA. One of many applications of modified cytidine nucleotides described herein is enzyme selection, when an enzyme of interest bears an activity of an esterase, amidase, oxidoreductase, lyase, ligase or other enzymatic activity, formula (I) wherein the substituants are as defined in the appended claims.

N-modified cytidine nucleotides and their use

The invention relates to novel PQQ-dependent soluble glucose dehydrogenases (sPQQGDH) which have an increased substrate specificity compared with the wild type, and also to methods for production and identification thereof.

Variants of PQQ-dependent glucose dehydrogenase having improved substrate specificity

The invention relates to novel PQQ-dependent soluble glucose dehydrogenases (sPQQGDH) fromand to a process for their preparation by overexpression in suitable microbial expression systems.

Glucose dehydrogenase and production thereof

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Vilnius, Lithuania

Rolandas Meskys