Umicore Ag & Co Kg

Graz University of Technology

Roche Palo Alto LLC

F. Hoffmann-la Roche Ag

Roland Winde

Ralf Karch

Andreas Rivas-Nass

Angelino Doppiu

Eileen Woerner

Christian Slugovc

Christina Schinagl

Michelangelo Scalone

Kurt Puentener

Oliver Briel

Andreas Rivas Nass

Bernd Kayser

Gerhard Peter

Jürgen Bodo Widmer

Nadine Langenscheidt

Wolfgang Hubert Meyer

Grant Stephen Forman

Robert Paul Tooze

Eileen Wörner

Stefanie Mayrhofer

Albrecht Salzer

Tina Schneider

Ralf Wilhelm Karch

The invention relates to a method for preparation of ruthenium-based carbene catalysts with a chelating alkylidene ligand ('Hoveyda-type catalysts') by reacting a penta coordinated ruthenium (II)-alkylidene complex of the type (L) (Py)X1X2Ru(alkylidene) with a suitable olefin derivative in a cross metathesis reaction. The method delivers high yields and is conducted preferably in aromatic hydrocarbon solvents. The use of phosphine-containing Ru carbene complexes as starting materials can be avoided. Catalyst products with high purity, particularly with low Cu content, can be obtained.

Method for preparation of ruthenium-based metathesis catalysts with chelating alkylidene ligands

The invention relates to ruthenium complexes which have a chiral diphosphorus donor ligand and in which the ruthenium has the oxidation state (+11) and the chiral diphosphorus donor ligand has bidentate P&#x2014;P coordination to the ruthenium. The ruthenium complexes are present in two forms (cationic type A and uncharged type B), are cyclic and have a four- to six-membered ring incorporating the diphosphorus donor ligand. The chiral diphosphorus donor ligands are selected from the group consisting of diphosphines, diphospholanes, diphosphites, diphosphonites and diazaphospholanes. Furthermore, processes for preparing the ruthenium complexes of types A and B, which are based on ligand exchange reactions, are described. The Ru complexes are used as catalysts for homogeneous asymmetric catalysis for preparing organic compounds.

Ruthenium complexes having (P&#x2014;P)&#x2014;coordinated diphosphorus donor ligands and processes for preparing them

The invention relates to a method for preparation of ruthenium-based carbene catalysts with a chelating alkylidene ligand ('Hoveyda-type catalysts') by reacting a penta-coordinated ruthenium (II)-alkylidene complex of the type (L) (Py)XXRu(alkylidene) with a suitable olefin derivative in a cross metathesis reaction. The method delivers high yields and is conducted preferably in aromatic hydrocarbon solvents. The use of phosphine-containing Ru carbene complexes as starting materials can be avoided. Catalyst products with high purity, particularly with low Cu content, can be obtained.

The present invention relates to a single-stage process for preparing dienyl-ruthenium complexes of the formula Ru(+II)(dienyl), wherein an Ru(II) starting compound of the formula Ru(X)(Y)is reacted with a diene ligand in the presence of an inorganic and/or organic base in a single-stage process. Here, polar organic solvents, preferably mixtures of polar organic solvents with water, are used. The dienyl-ruthenium complexes prepared according to the invention are used as precursors for homogeneous catalysts, for producing functional coatings and for therapeutic applications.

Process for preparing dienyl-ruthenium complexes

The present invention relates to a process for preparing ruthenium(0)-olefin complexes of the (arene)(diene)Ru(0) type by reacting a ruthenium starting compound of the formula Ru(+II)(X)(Y)(in which X=an anionic group, Y=an uncharged two-electron donor ligand, p=1 or 2, q=an integer from 1 to 6), with a cyclohexadiene derivative or a diene mixture comprising a cyclohexadiene derivative, in the presence of a base. In this process, the arene bound in the (arene)(diene)Ru(0) complex is formed from this cyclohexadiene derivative by oxidation. Suitable ruthenium(II) starting compounds are, for example, RuCl(acetonitrile), RuCl(pyridine)or RuCl(DMSO). The bases used are inorganic or organic bases. The ruthenium(0)-olefin complexes prepared by the process according to the invention have a high purity and can be used as precursors for homogeneous catalysts, for preparation of functional ruthenium- or ruthenium oxide-containing layers and for therapeutic applications.

Process for preparing ruthenium(0)-olefin complexes

The present invention is directed to a method for the preparation of ruthenium indenylidene carbene catalysts of the type (L)(L')XRu(II)(aryl-indenylidene). The method comprises the steps of reacting the precursor compound Ru(PPh)X(n=3-4) with a propargyl alcohol derivative in an cyclic diether solvent such as 1,4-dioxane at temperatures in the range of 80 to 130&#xb0; C. and reaction times of 1 to 60 minutes. Optionally, additional neutral electron donor ligands such as PCy, phobane ligands or NHC ligands are added to the reaction mixture for ligand exchange. The method includes a precipitation step for purification, after which the product is isolated. The ruthenium-indenylidene carbene catalysts are obtained in high purity and are used as catalysts for metathesis reactions (RCM, ROMP and CM) and as precursors for the synthesis of modified ruthenium carbene catalysts.

Method for preparation of ruthenium-indenylidene carbene catalysts

The invention relates to ruthenium complexes with a chiral ferrocenyldiphosphine ligand, wherein the ruthenium has the oxidation state (+II) and the chiral ferrocenyldiphosphine ligand has bidentate P&#x2014;P coordination to the ruthenium. The ruthenium complexes are cyclic and with the ferrocenyldiphosphine ligand have an at least eight-membered ring. The ferrocenyldiphosphine ligands are selected from the group consisting of Taniaphos, Taniaphos-OH and Walphos ligands. A process for preparing the Ru complexes is described. The Rn complexes are used as catalysts for homogeneous asymmetric catalysis for preparing organic compounds.

Ruthenium complexes with (P&#x2014;P)-coordinated ferrocenyldiphosphine ligands, process for preparing them and their use in homogeneous catalysis

The invention relates to a novel process for the preparation of Ruthenium metathesis catalysts of the formula  Ruthenium metathesis catalysts have been widely applied in the synthesis of macrocyclic drug compounds.

Process for the preparation a ruthenium complex

The present invention relates to a process for the preparation of indium acetate comprising the steps: (a) reacting an indium compound with an alkaline compound in a protic solvent to obtain an iridium containing precipitate, where the reaction is conducted in the presence of at least one component (i) selected from oxalic acid, a salt of oxalic acid, formic acid and a salt of formic acid, (b) reacting the precipitate in the presence of at least (i) one compound selected from oxalic acid, a salt of oxalic acid, formic acid and a salt of formic acid, and (ii) CHCOH and/or CH(CO)O(CO)CHto give an iridium acetate containing solution. The invention also relates to indium acetate having a low halide content, to an indium containing precipitate and to uses of the iridium containing precipitate of the present invention and the iridium acetate of the present invention.

Process for the preparation of iridium acetate

According to the present invention there is provided a compound in the form of a transition metal compound including a transition metal, a phosphorus containing ligand, and a cyclic organic ligand. The phosphorus containing ligand is a heterocyclic organic compound with a ligating phosphorus atom which ligates with the transition metal, and which ligating phosphorus atom is an atom in the heterocyclic ring structure of the heterocyclic organic compound. The cyclic organic ligand is a cyclic organic compound with a ligating carbon atom in the cyclic ring structure of the cyclic organic compound which ligates with the transition metal by means of a double bound. The invention also relates to a method preparing such a compound and a metathesis reaction wherein such a compound is used as a catalyst.

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Frankfurt-am-Main, Germany

Roland Winde