Genesoft Pharmaceuticals, Inc.

Oscient Pharmaceuticals Corporation

Genesoft Pharmceuticals, Inc.

Roland W Bürli

Jacob A Kaizerman

Eldon E Baird

Matthew J Taylor

Yigong Ge

Heinz Ernst Moser

Peter Jones

Wenhao Hu

Amanda E Martin

Brie Cadman

Antipathogenic benzamide compounds having the formula wherein at least one of the Rgroups is F, Cl, CN or CFand R, R, Y, Z, m, and n are as defined herein.

Antipathogenic benzamide compounds

Compounds of the formula (I) where Ar and R are as defined herein, possess antibacterial properties.

Antibacterial compounds having a (pyrrole carboxamide)-(benzamide)-(imidazole carboxamide) motif

Halogen substituted thienyl compounds exhibit potential as nucleic acid (especially double stranded DNA) binders and as antibiotic compounds. A representative thienyl compound has the structure 

Halogen-substitued thienyl compounds

Charged compounds are provided that comprise one or more regions of localized positive charge, compositions comprising such compounds, methods of synthesizing such compounds, methods of screening such compounds to identify those having anti-infective activity, and methods of using such compounds to prevent or inhibit infections. These compounds, and compositions containing them, have multiple applications, including use in human and animal medicine and in agriculture.

Charged compounds comprising a nucleic acid binding moiety and uses therefor

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Pasadena, CA, United States of America

Roland W Bürli