University of California

California Institute of Technology

University of Louisville Research Foundation, Inc.

Neurorecovery Technologies, Inc.

Roland R Roy

Yury P Gerasimenko

Victor Reggie Edgerton

Yu-Chong Tai

Susan Jill Harkema

Joel W Burdick

Daniel C Lu

Claudia A Angeli

Mandheerej S Nandra

Thomas Anthony Desautels

Jonathan Hodes

V Reggie Edgerton

John F Naber

Robert S Keynton

Nicholas A Terrafranca

Douglas J Jackson

Steven L Upchurch

Damien Craig Rodger

Yangsheng Chen

Andy Fong

Susan J Harkema

Parag Gad

Yuri P Gerasimenko

Igor Lavrov

Yangshen Chen

Hui Zhong

Jr Nicholas A Terrafranca

Joel Burdick

In various embodiments, non-invasive methods to induce motor control in a mammal subject to spinal cord or other neurological injuries are provided. In some embodiments the methods involve administering transcutaneous electrical spinal cord stimulation (tSCS) to the mammal at a frequency and intensity that induces locomotor activity.

Multi-site transcutaneous electrical stimulation of the spinal cord for facilitation of locomotion

In various embodiments, methods are provided for applying transcutaneous and/or epidural spinal cord stimulation with and without selective pharmaceuticals to restore voluntary control of hand function in tetraplegic subjects.

Engaging the cervical spinal cord circuitry to re-enable volitional control of hand function in tetraplegic subjects

Methods of enabling locomotor control, postural control, voluntary control of body movements (e.g., in non-weight bearing conditions), and/or autonomic functions in a human subject having a spinal cord injury, a brain injury, or a neurological neuromotor disease are described.

High density epidural stimulation for facilitation of locomotion, posture, voluntary movement, and recovery of autonomic, sexual, vasomotor, and cognitive function after neurological injury

Method of transcutaneous electrical spinal cord stimulation for facilitation of locomotion

Methods comprising applying electrical stimulation to patients in conjunction with physical training are described.

This disclosure provides non-invasive methods to induce motor control in a mammal subject to spinal cord or other neurological injuries. In certain embodiments the method involves administering transcutaneous electrical spinal cord stimulation (tSCS) to the mammal at a frequency and intensity that induces the desired locomotor activity.

Transcutaneous spinal cord stimulation: noninvasive tool for activation of locomotor circuitry

In various embodiments methods and devices are provided for regulating bladder function in a subject after a spinal cord and/or brain injury. In certain embodiments the methods comprise applying a pattern of electrical stimulation to the Lumbosacral spinal cord at a frequency and intensity sufficient to initiate micturition and/or to improve the amount of bladder emptying. In certain embodiments the electrical stimulation is at a frequency and intensity sufficient to improve the amount of bladder emptying (e.g., to provide at least 30% emptying or at least 40% emptying, or at least 50% emptying, or at least 60% emptying, or at least 70% emptying, or at least 80% emptying, or at least 90% emptying, or at least 95% emptying.

Regulation of autonomic control of bladder voiding after a complete spinal cord injury

Neurostimulator devices are described. An example neurostimulator device includes a stimulation assembly connectable to a plurality of electrodes, wherein the plurality of electrodes are configured to stimulate a spinal cord. The neurostimulator device also includes an interface and at least one processor configured to modify at least one complex stimulation pattern deliverable by the plurality of electrodes by integrating data from the interface and performing a machine learning algorithm on the at least one complex stimulation pattern.

Neurostimulator

Neurostimulator devices are described comprising: a stimulation assembly connectable to a plurality of electrodes, wherein the plurality of electrodes are configured to stimulate a spinal cord; one or more sensors; and at least one processor configured to modify at least one complex stimulation pattern deliverable by the plurality of electrodes by integrating data from the one or more sensors and performing a machine learning method implementing a Gaussian Process Optimization on the at least one complex stimulation pattern. Methods of use are also described.

Neurostimulator devices using a machine learning method implementing a gaussian process optimization

Methods of enabling locomotor control, postural control, voluntary control of body movements (e.g., in non-weight bearing conditions), and/or autonomic functions in a human subject having spinal cord injury, brain injury, or neurological neuromotor disease are described.

An implantable electrode array assembly configured to apply electrical stimulation to the spinal cord. A substantially electrically nonconductive layer of the device has a first portion positionable alongside the spinal cord that includes a plurality of first openings. The layer has a second portion that includes a plurality of second openings. Electrodes and traces are positioned inside a peripheral portion of a body portion of the device and alongside the layer. At least one of the first openings is adjacent each of the electrodes to provide a pathway through which the electrode may provide electrical stimulation to the spinal cord. At least one of the second openings is adjacent each of the traces to provide a pathway through which the trace may receive electrical stimulation. At least one trace is connected to each electrode and configured to conduct electrical stimulation received by the trace(s) to the electrode.

Method of constructing an implantable microelectrode array

Growing community of inventors

Playa Vista, CA, United States of America

Roland R Roy