University System of Maryland

University of Glasgow

Roland Probst

Benjamin Shapiro

Satej V Chaudhary

Michael D Armani

Declan Andrew Diver

Hugh Potts

Andreas Lüebbe

Systems and methods are disclosed for trapping or focusing magnetizable particles comprising therapeutic agents at a distance using a dynamic magnetic field and feedback control, to enable the treatment of diseased areas deep inside a patient's body. The methods may be used to diagnose or treat diseased areas deep within a patient, for example tumors of the lungs, intestines, and liver, and is also useful in enhancing the permeability of solid tumors to chemotherapeutic agents.

Methods and systems for magnetic focusing of therapeutic, diagnostic or prophylactic agents to deep targets

In a microfluidic device, respective motion of a plurality of objects along corresponding trajectories is achieved by determining a force field, such as an underlying fluid flow which, when applied to the plurality of object, moves each object along its corresponding trajectory. The force field is a linear superposition of a subset of all force fields supported by the physical characteristics of the microfluidic device. Once the fields have been ascertained, a plurality of actuation signals corresponding to the fields is applied to actuators installed on the microfluidic device to cause the force on each object. By implementing a feedback structure, corrections for positional errors may be made by computing a corrective force for each object and adjusting the actuation signals appropriately thereto.

Arbitrary and simultaneous control of multiple objects in micro-fluidic systems

Arbitrary and simultaneous control of multiple objects in microfluidic systems

Growing community of inventors

College Park, MD, United States of America

Roland Probst