Boehringer Ingelheim International Gmbh

Orexo Ab

Boehringer Ingelheim Pharma Gmbh & Co Kg

Roland Pfau

Henning Priepke

Kai Gerlach

Wolfgang Wienen

Herbert Nar

Georg Dahmann

Annette Schuler-Metz

Raimund Kuelzer

Henri Doods

Sandra Handschuh

Dirk Stenkamp

Norbert Hauel

Benjamin Pelcman

Robert Roenn

Kirsten Arndt

Dieter Wiedenmayer

Klaus Klinder

Riccardo Giovannini

Angelo Ceci

Cornelia Dorner-Ciossek

Juergen Mack

Iris Kauffmann-Hefner

Edgars Suna

Dimitrijs Lubriks

Eckhart Bauer

Klaus Rudolf

Stefan Peters

Uwe Joerg Ries

James Gillard

Alexander Heim-Riether

Anton Pekcec

Lothar Kussmaul

Stefan Just

Peter Kuehn

Johann Faustus Du Hoffmann

Christoph Hohn

Christian Specker

Heiko Sommer

Riccardo Giovaninni

Julia Schlichtiger

Thorsten Lehmann

Annette Maria Schuler-Metz

Sandra Ruth Handschuh

The present invention relates to compounds of formula I a process for their manufacture, pharmaceutical compositions containing them and their use in therapy, particularly in the treatment and/or prevention of conditions having an association with the function of metabotropic glutamate receptor subtype 4 (mGluR4). A, R, R, R, R, Rand Rhave meanings given in the description.

Substituted pyrazine-carboxamide derivatives

Disclosed are 4-pyrazin-2-ylmethyl-morpholines of formula A and pharmaceutically acceptable salts thereof, wherein Rand Rare defined herein. Also disclosed are processes for their preparation, pharmaceutical compositions containing the compounds, and their use in therapy, particularly in the treatment or prevention of conditions having an association with NR2B negative allosteric modulating properties.

4-pyrazin-2-ylmethyl-morpholine derivatives and the use thereof as medicament

Disclosed are 4-pyridinylmethyl-morpholines of formula A and pharmaceutically acceptable salts thereof, wherein Rand Rare defined herein. Also disclosed are processes for their preparation, pharmaceutical compositions containing the compounds, and their use in therapy, particularly in the treatment or prevention of conditions having an association with NR2B negative allosteric modulating properties.

4-pyridinylmethyl-morpholine derivatives and the use thereof as medicament

Disclosed are 4-pyrimidin-5-ylmethyl-morpholines of formula A and pharmaceutically acceptable salts thereof, wherein Rand Rare defined herein. Also disclosed are processes for their preparation, pharmaceutical compositions containing the compounds, and their use in therapy, particularly in the treatment or prevention of conditions having an association with NR2B negative allosteric modulating properties.

4-pyrimidin-5-ylmethyl-morpholine derivatives and the use thereof as medicament

The present invention relates to imidazopyridines of formula A processes for their preparation, pharmaceutical compositions containing them and their use in therapy, particularly in the treatment or prevention of conditions having an association with NR2B negative allosteric modulating properties.

Imidazopyridine derivatives and the use thereof as medicament

The present invention relates to new substituted glycinamides of general formula (I) wherein D, M, R, Rand Rare defined as in the specification, the tautomers, enantiomers, diastereomers, mixtures and salts thereof, particularly the physiologically acceptable salts thereof with inorganic or organic acids or bases, which have valuable properties.

Substituted glycinamides, process for their manufacture and use thereof as medicaments

There are provided compounds of formula (I), wherein R, R, R, Q, Q, Q, Q, L and A have meanings given in the description, and pharmaceutically-acceptable salts thereof, which compounds are useful in the treatment of diseases in which inhibition of the activity of a member of the MAPEG family is desired and/or required, and particularly in the treatment of inflammation and/or cancer. 

1H-benzimidazole-5-carboxamides as anti-inflammatory agents

This invention relates to compounds of formula I, their use as inhibitors of the microsomal prostaglandin Esynthase-1 (mPGES-1), pharmaceutical compositions containing them, and their use as medicaments for the treatment and/or prevention of inflammatory diseases and associated conditions such as inflammatory/nociceptive pain. A, M, R, R, R, R, R, Q, Q, Q, Z, Z, Z, Zand W have meanings given in the description.

Compounds

The present invention relates to compounds of general formula I in which A, L, M, Q, Q, Q, R, R, R, R, R, W, X, Y, Z, Z, Zare defined in the description, the salts thereof, particularly the physiologically acceptable salts thereof. The compounds are of potential utility in the treatment and/or prevention of inflammatory diseases and associated conditions, in particular, in the treatment and/or prevention of pain. The invention also relates to the use of such compounds as medicaments, to pharmaceutical compositions containing them, and to their preparation.

1H-benz imidazole-5-carboxamides as anti-inflammatory agents

The present invention relates to new substituted carboxylic acid amides of general formula wherein A, B and Rto Rare defined as in claim, the tautomers, the enantiomers, the diastereomers, the mixtures thereof and the salts thereof, particularly the physiologically acceptable salts thereof with inorganic or organic acids or bases, which have valuable properties.

Carboxylic acid amides, the preparation thereof and their use as medicaments

This invention relates to compounds of formula I their use as inhibitors of the microsomal prostaglandin Esynthase-1 (mPGES-1), pharmaceutical compositions containing them, and their use as medicaments for the treatment and/or prevention of inflammatory diseases and associated conditions. A, M, W, R, R, R, R, Rhave meanings given in the description.

3H-imidazo [4, 5-C] pyridine-6-carboxamides as anti-inflammatory agents

3H-imidazo [4, 5-B] pyridine-6-carboxamides as anti-inflammatory agents

This invention relates to compounds of formula I their use as inhibitors of the microsomal prostaglandin Esynthase-1 (mPGES-1), pharmaceutical compositions containing them, and their use as medicaments for the treatment and/or prevention of inflammatory diseases and associated conditions. A, L, M, W, R, R, R, R, R, R, R, R, Rhave meanings given in the description.

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Biberach, Germany

Roland Pfau