Phylogica Limited

Fox Chase Cancer Center

Institute for Cancer Research

Roland L Dunbrack

Gregory P Adams

Paul Michael Watt

Matthew K Robinson

Heidi H Simmons

Jared Adolf-Bryfogle

Andreas Lehmann

Recombinant proteins that comprise a bone morphogenic protein 2 backbone onto which was grafted a M&#xfc;llerian-inhibiting substance type II receptor binding region of the M&#xfc;llerian-inhibiting substance protein are provided. These proteins bind to this receptor on the surface of epithelial cancer cells, and induce apoptosis of such cells. These proteins are useful, for example, in the treatment of cancers such as ovarian, uterine, endometrial, fallopian tube, breast, prostate, and lung cancers.

Chimera of bone morphogenic protein 2 and the M&#xfc;llerian-inhibiting substance type II receptor binding region of M&#xfc;llerian-inhibiting substance

Methods for generating hybrid antibodies are provided.

Rationally-designed anti-mullerian inhibiting substance type II receptor antibodies

The present invention provides the means for producing libraries of peptide structures for drug screening applications that are capable of folding or assuming their native conformations independently of artificial scaffolds or flanking sequences in the proteins from which they are derived. The libraries can be highly diverse such that they are representative of the repertoire of protein structures existing in nature. The libraries can also be non-redundant or normalized such that the bias towards specific structures existing in source data sets and/or in nature is/are removed. In a particularly preferred embodiment, the present invention provides 30,000 independent fold structures produced by this method. The present invention also provides computer-readable media and systems comprising structural data in relation to the peptide libraries, and methods for displaying and screening the libraries.

Methods of constructing and screening libraries of peptide structures

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Philadelphia, PA, United States of America

Roland L Dunbrack