Bracco International Bv

Bracco Research Sa

Sintetica S.a.

Roland Hyacinthe

Herve Tournier

Michel Schneider

Friedrich Cavagna

Bernard Lamy

Christian Guillot

Composition for diagnostic or therapeutic use which comprises an assembly comprising an active agent. The assembly comprises a liposome and a plurality of micellar components associated thereto, said micellar components being associated to the outer surface of the envelope of said liposome through a substantially electrostatic interaction, When an active compound is incorporated into the micelles, a substantial amount of said active compound can be linked to a singe liposome. Furthermore, the presence of the outer micellar layer allows to increase the residence time of said liposome in the blood stream.

Liposomal assembly for therapeutic and/or diagnostic use

The invention concerns NMR imaging contrast compositions comprising magnetically responsive species coupled to physiologically acceptable amphipatic organic substrate materials in the form of mixed micelles suspended or dispersed in a physiologically acceptable aqueous liquid carrier. The compositions are particularly useful for diagnostic investigations of the blood-pool. The invention also concerns the preparation of the mixed micelles, as well as of injectable compositions containing the mixed micelles as contrast agents for MRI purpose. Once injected, the mixed micelles of the compositions behave as imaging contrast enhancers, e.g. they will improve the quality and resolution of the electronically processed images obtained during MRI examinations of the circulation and/or circulation targeted organs. The compositions are formulated to protect the particles of the contrast agents from early removal by the reticulo-endothelial (RES) system of the liver and the spleen, so that they will stay in the circulation for a time sufficient to properly image the blood vessels and to be transported to selected organs. MRI imaging of the circulation and of targeted organs can strongly assist in diagnosing possible ailments in human and animal patients.

Blood-pool imaging composition comprising micelles containing a

Suspensions of either echogenic or magnetic particles in aqueous bioadhesive carriers effectively improve imaging by echography, respectively NMRI, of the digestive tract. Affinity of the compositions for the gastric mucosa can be adapted to the needs by appropriately selecting the carrier in function to inherent bioadhesive capacity: this technique leads to improved visualization of selected portions of the lumen.

Polymers and copolymers of acrylic acid MRI of the digestive tract of

Mucoadhesive compositions for increasing the ultrasonic image contrast

Compositions for increasing the image contrast in diagnostic

Magnetite particles suitable for injection into the blood stream of patients having enhanced resistance against agglomeration and uptake by the RES of the liver and spleen. The particles essentially consist of an iron oxide core and a phosphoric acid mono alkyl or alkenyl ester or glycerophospholipid/surfactant three dimensional shell surrounding the core. The core and the monoester or a micellar glycerophospholipid form an urchin-like structure which is further interlaced or intertwined with a non-ionic surfactant to produce a protective three dimensional shell which renders particles almost undetectable by the macrophages. Particles prepared according to the invention are kept in the blood circulation for long periods and represent excellent long lasting blood pool agents. Key components in the shell are (a) a polybasic mineral-organic species such as glycero phosphatidic acid in micellar form and (b) a block copolymer having successive hydrophilic and hydrophobic segments.

Process of preparing particles for NMR imaging

Method of imaging using encapsulated magnetite particles

Particles for NMR imaging

Method for making liposomes of enhanced entrapping capacity toward

Method of making an ingestible composition useful as a contrast enhancing agent in ultrasonic imaging of the digestive tract of humans and animals, wherein the composition has microballoons as contrast enhancing particles bound to an organic carrier phase, which when hydrated has an adhesive affinity for the gastrointestinal mucosa. Method includes grafting a silane coupler having at least two reactive functions to the microballoons through one of the reactive functions and binding the grafted microballoons to the carrier phase through another reactive function.

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Douvaine, France

Roland Hyacinthe