Bayer Aktiengesellschaft

Roland Fischer

Matthias Beller

Manfred Neumann

Lutz-F Tietze

Lutz-Friedjan Tietze

Compounds of the formula (I) ##STR1## wherein R.sup.1 represents a pyranosyl radical and R.sup.4, R.sup.2, and R.sup.3 are as specified herein, compositions containing the compounds, methods of using the compounds to selectively kill tumor cells, and a process for the preparation of the compounds.

Ketophosphamide glycosides

Compounds of the formula ##STR1## in which R.sup.1 represents saturated, unsaturated or anhydro desoxypentosyl, desoxyhexosyl or didesoxyhexosyl, where the OH functions of the sugar are optionally protected, and

Aldophosphamide glycosides, a process for their preparation and their

The invention relates to a process for the synthesis of 1,1'-diacetals, which method is also suitable for the stereoselective synthesis of glycosides with the 1,1'-diacetal structure. The process involves reacting a silyl compound of formula (II) with an acetal of formula (III) in the presence of a catalyst of formula (IV) or (V) in a suitable solvent.

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Bovenden, Germany

Roland Fischer