Ucb Pharma Gmbh

Schwarz Pharma Ag

Schwarz Pharma Limited

Roland Drews

Claus Meese

Hans-Michael Wolff

Armin Breitenbach

Seth C Ennis

Seth Ennis

The invention relates to a compound of general formula (I) wherein A represents deuterium or hydrogen, R represents a group selected from Calkyl, Ccycloalkyl or phenyl, which can be substituted by C1-3 alkoxy, fluorine, chlorine, bromine, iodine, nitro, amino, hydroxyl, oxo, mercapto or deuterium. The C atom marked with a * (star) can be present in an (R) configuration, in an (S)-configuration or a mixture thereof. The invention is characterized in that the above-mentioned compounds are free bases with a degree of purity of more than 97 wt %. The invention also relates to a method for the production of highly pure compounds of general formula (I) and to the use thereof in the production of medicaments. 

High purity bases of 3,3-diphenylpropylamino monoesters

The present invention provides a process for the production of a compound of formula (I) or a salt thereof, wherein R is hydrogen, a straight, branched or cyclic C-Calkyl group or an aryl group which may optionally be substituted. This process comprises: (a) reacting a compound of formula (II), with a compound of formula (III), wherein R is as defined above and X is a leaving group, in the presence of N,N-di-isopropylethylamine. 

Synthesis of phenolic esters of hydroxymethyl phenols

The invention relates to a device for transdermally administering a compound of formula (I), wherein A represents hydrogen or deuterium, R represents a group selected among Calkyl, Ccycloalkyl, or phenyl, each of which can be substituted by Calkoxy, fluoride, chlorine, bromine, iodine, nitro, amino, hydroxy, oxo, mercapto, or deuterium, the C atom marked by * (asterisk) being provided in the R configuration. The invention is characterized in that the compound of general formula (I) is provided in a polymer matrix and is released at a dose of 0.5 to 20 mg per day through human skin. The invention further relates to the use of said compounds of formula (I) for producing transdermal medicaments. 

Transdermal delivery of (R)-3,3-diphenylpropylamin-monoestern

Transdermal administration of (R)-3,3-diphenylpropylamin-monoesters

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Monheim, Germany

Roland Drews